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Impact of Resolution of Hyponatremia on Neurocognitive and Motor Performance in Geriatric Patients
This observational study investigated the impact of hyponatremia resolution on the results of a comprehensive geriatric assessment (CGA) in 150 patients with age ≥70 years and serum sodium <130 mEq/L. The test battery including Barthel index of Activities of Daily Living (ADL) and various tests o...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715723/ https://www.ncbi.nlm.nih.gov/pubmed/31467370 http://dx.doi.org/10.1038/s41598-019-49054-8 |
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author | Brinkkoetter, Paul Thomas Grundmann, Franziska Ghassabeh, Panteha Jazayeri Becker, Ingrid Johnsen, Marc Suaréz, Victor Schulz, Ralf-Joachim Streichert, Thomas Burst, Volker |
author_facet | Brinkkoetter, Paul Thomas Grundmann, Franziska Ghassabeh, Panteha Jazayeri Becker, Ingrid Johnsen, Marc Suaréz, Victor Schulz, Ralf-Joachim Streichert, Thomas Burst, Volker |
author_sort | Brinkkoetter, Paul Thomas |
collection | PubMed |
description | This observational study investigated the impact of hyponatremia resolution on the results of a comprehensive geriatric assessment (CGA) in 150 patients with age ≥70 years and serum sodium <130 mEq/L. The test battery including Barthel index of Activities of Daily Living (ADL) and various tests of neurocognitive function, motor performance and mood stability was applied on admission and at discharge. Changes of individual test results (Δ) were analyzed and normonatremic patients matched for age, gender, and ADL served as reference group. Most CGA test results improved. The improvement was more pronounced in the hyponatremia group with respect to ADL (ΔADL: 14.3 ± 17.1 vs. 9.8 ± 14.7; p = 0.002) and MMSE (ΔMMSE: 1.8 ± 3.0 vs. 0.7 ± 1.9; p = 0.002). Effect sizes were small (i.e., >0.2) in the overall analysis for ΔADL and ΔMMSE and moderate (i.e., >0.5) for ΔMMSE in the euvolemic subgroup. Beneficial effects on ΔADL and ΔMMSE were only observed in the subgroup of patients in which [Na(+)] was raised by >5 mEq/L and multivariable linear regression analysis confirmed [Na(+)] increase to be an independent predictor of MMSE improvement. Resolution of hyponatremia has a beneficial impact on the geriatric patients’ overall functional status, in particular in euvolemic cases. |
format | Online Article Text |
id | pubmed-6715723 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-67157232019-09-13 Impact of Resolution of Hyponatremia on Neurocognitive and Motor Performance in Geriatric Patients Brinkkoetter, Paul Thomas Grundmann, Franziska Ghassabeh, Panteha Jazayeri Becker, Ingrid Johnsen, Marc Suaréz, Victor Schulz, Ralf-Joachim Streichert, Thomas Burst, Volker Sci Rep Article This observational study investigated the impact of hyponatremia resolution on the results of a comprehensive geriatric assessment (CGA) in 150 patients with age ≥70 years and serum sodium <130 mEq/L. The test battery including Barthel index of Activities of Daily Living (ADL) and various tests of neurocognitive function, motor performance and mood stability was applied on admission and at discharge. Changes of individual test results (Δ) were analyzed and normonatremic patients matched for age, gender, and ADL served as reference group. Most CGA test results improved. The improvement was more pronounced in the hyponatremia group with respect to ADL (ΔADL: 14.3 ± 17.1 vs. 9.8 ± 14.7; p = 0.002) and MMSE (ΔMMSE: 1.8 ± 3.0 vs. 0.7 ± 1.9; p = 0.002). Effect sizes were small (i.e., >0.2) in the overall analysis for ΔADL and ΔMMSE and moderate (i.e., >0.5) for ΔMMSE in the euvolemic subgroup. Beneficial effects on ΔADL and ΔMMSE were only observed in the subgroup of patients in which [Na(+)] was raised by >5 mEq/L and multivariable linear regression analysis confirmed [Na(+)] increase to be an independent predictor of MMSE improvement. Resolution of hyponatremia has a beneficial impact on the geriatric patients’ overall functional status, in particular in euvolemic cases. Nature Publishing Group UK 2019-08-29 /pmc/articles/PMC6715723/ /pubmed/31467370 http://dx.doi.org/10.1038/s41598-019-49054-8 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Brinkkoetter, Paul Thomas Grundmann, Franziska Ghassabeh, Panteha Jazayeri Becker, Ingrid Johnsen, Marc Suaréz, Victor Schulz, Ralf-Joachim Streichert, Thomas Burst, Volker Impact of Resolution of Hyponatremia on Neurocognitive and Motor Performance in Geriatric Patients |
title | Impact of Resolution of Hyponatremia on Neurocognitive and Motor Performance in Geriatric Patients |
title_full | Impact of Resolution of Hyponatremia on Neurocognitive and Motor Performance in Geriatric Patients |
title_fullStr | Impact of Resolution of Hyponatremia on Neurocognitive and Motor Performance in Geriatric Patients |
title_full_unstemmed | Impact of Resolution of Hyponatremia on Neurocognitive and Motor Performance in Geriatric Patients |
title_short | Impact of Resolution of Hyponatremia on Neurocognitive and Motor Performance in Geriatric Patients |
title_sort | impact of resolution of hyponatremia on neurocognitive and motor performance in geriatric patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715723/ https://www.ncbi.nlm.nih.gov/pubmed/31467370 http://dx.doi.org/10.1038/s41598-019-49054-8 |
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