Drug delivery to retinal photoreceptors

The photoreceptors of the retina are afflicted by diseases that still often lack satisfactory treatment options. Although suitable drugs might be available in some cases, the delivery of these compounds into the eye and across the blood–retinal barrier remains a significant challenge for therapy dev...

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Autores principales: Himawan, Erico, Ekström, Per, Buzgo, Matej, Gaillard, Pieter, Stefánsson, Einar, Marigo, Valeria, Loftsson, Thorsteinn, Paquet-Durand, François
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science Ltd. ;, Distributed by Virgin Mailing and Distribution 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715772/
https://www.ncbi.nlm.nih.gov/pubmed/30877076
http://dx.doi.org/10.1016/j.drudis.2019.03.004
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author Himawan, Erico
Ekström, Per
Buzgo, Matej
Gaillard, Pieter
Stefánsson, Einar
Marigo, Valeria
Loftsson, Thorsteinn
Paquet-Durand, François
author_facet Himawan, Erico
Ekström, Per
Buzgo, Matej
Gaillard, Pieter
Stefánsson, Einar
Marigo, Valeria
Loftsson, Thorsteinn
Paquet-Durand, François
author_sort Himawan, Erico
collection PubMed
description The photoreceptors of the retina are afflicted by diseases that still often lack satisfactory treatment options. Although suitable drugs might be available in some cases, the delivery of these compounds into the eye and across the blood–retinal barrier remains a significant challenge for therapy development. Here, we review the routes of drug administration to the retina and highlight different options for drug delivery to the photoreceptor cells.
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spelling pubmed-67157722019-09-04 Drug delivery to retinal photoreceptors Himawan, Erico Ekström, Per Buzgo, Matej Gaillard, Pieter Stefánsson, Einar Marigo, Valeria Loftsson, Thorsteinn Paquet-Durand, François Drug Discov Today Article The photoreceptors of the retina are afflicted by diseases that still often lack satisfactory treatment options. Although suitable drugs might be available in some cases, the delivery of these compounds into the eye and across the blood–retinal barrier remains a significant challenge for therapy development. Here, we review the routes of drug administration to the retina and highlight different options for drug delivery to the photoreceptor cells. Elsevier Science Ltd. ;, Distributed by Virgin Mailing and Distribution 2019-08 /pmc/articles/PMC6715772/ /pubmed/30877076 http://dx.doi.org/10.1016/j.drudis.2019.03.004 Text en © 2019 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Himawan, Erico
Ekström, Per
Buzgo, Matej
Gaillard, Pieter
Stefánsson, Einar
Marigo, Valeria
Loftsson, Thorsteinn
Paquet-Durand, François
Drug delivery to retinal photoreceptors
title Drug delivery to retinal photoreceptors
title_full Drug delivery to retinal photoreceptors
title_fullStr Drug delivery to retinal photoreceptors
title_full_unstemmed Drug delivery to retinal photoreceptors
title_short Drug delivery to retinal photoreceptors
title_sort drug delivery to retinal photoreceptors
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715772/
https://www.ncbi.nlm.nih.gov/pubmed/30877076
http://dx.doi.org/10.1016/j.drudis.2019.03.004
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