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Early Brain Injury After Poor-Grade Subarachnoid Hemorrhage
PURPOSE OF REVIEW: Over the last years, the focus of clinical and animal research in subarachnoid hemorrhage (SAH) shifted towards the early phase after the bleeding based on the association of the early injury pattern (first 72 h) with secondary complications and poor outcome. This phase is commonl...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715808/ https://www.ncbi.nlm.nih.gov/pubmed/31468197 http://dx.doi.org/10.1007/s11910-019-0990-3 |
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author | Rass, Verena Helbok, Raimund |
author_facet | Rass, Verena Helbok, Raimund |
author_sort | Rass, Verena |
collection | PubMed |
description | PURPOSE OF REVIEW: Over the last years, the focus of clinical and animal research in subarachnoid hemorrhage (SAH) shifted towards the early phase after the bleeding based on the association of the early injury pattern (first 72 h) with secondary complications and poor outcome. This phase is commonly referenced as early brain injury (EBI). In this clinical review, we intended to overview commonly used definitions of EBI, underlying mechanisms, and potential treatment implications. RECENT FINDINGS: We found a large heterogeneity in the definition used for EBI comprising clinical symptoms, neuroimaging parameters, and advanced neuromonitoring techniques. Although specific treatments are currently not available, therapeutic interventions are aimed at ameliorating EBI by improving the energy/supply mismatch in the early phase after SAH. SUMMARY: Future research integrating brain-derived biomarkers is warranted to improve our pathophysiologic understanding of EBI in order to ameliorate early injury patterns and improve patients’ outcomes. |
format | Online Article Text |
id | pubmed-6715808 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-67158082019-09-13 Early Brain Injury After Poor-Grade Subarachnoid Hemorrhage Rass, Verena Helbok, Raimund Curr Neurol Neurosci Rep Critical Care (Stephan A. Mayer, Section Editor) PURPOSE OF REVIEW: Over the last years, the focus of clinical and animal research in subarachnoid hemorrhage (SAH) shifted towards the early phase after the bleeding based on the association of the early injury pattern (first 72 h) with secondary complications and poor outcome. This phase is commonly referenced as early brain injury (EBI). In this clinical review, we intended to overview commonly used definitions of EBI, underlying mechanisms, and potential treatment implications. RECENT FINDINGS: We found a large heterogeneity in the definition used for EBI comprising clinical symptoms, neuroimaging parameters, and advanced neuromonitoring techniques. Although specific treatments are currently not available, therapeutic interventions are aimed at ameliorating EBI by improving the energy/supply mismatch in the early phase after SAH. SUMMARY: Future research integrating brain-derived biomarkers is warranted to improve our pathophysiologic understanding of EBI in order to ameliorate early injury patterns and improve patients’ outcomes. Springer US 2019-08-29 2019 /pmc/articles/PMC6715808/ /pubmed/31468197 http://dx.doi.org/10.1007/s11910-019-0990-3 Text en © The Author(s) 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Critical Care (Stephan A. Mayer, Section Editor) Rass, Verena Helbok, Raimund Early Brain Injury After Poor-Grade Subarachnoid Hemorrhage |
title | Early Brain Injury After Poor-Grade Subarachnoid Hemorrhage |
title_full | Early Brain Injury After Poor-Grade Subarachnoid Hemorrhage |
title_fullStr | Early Brain Injury After Poor-Grade Subarachnoid Hemorrhage |
title_full_unstemmed | Early Brain Injury After Poor-Grade Subarachnoid Hemorrhage |
title_short | Early Brain Injury After Poor-Grade Subarachnoid Hemorrhage |
title_sort | early brain injury after poor-grade subarachnoid hemorrhage |
topic | Critical Care (Stephan A. Mayer, Section Editor) |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715808/ https://www.ncbi.nlm.nih.gov/pubmed/31468197 http://dx.doi.org/10.1007/s11910-019-0990-3 |
work_keys_str_mv | AT rassverena earlybraininjuryafterpoorgradesubarachnoidhemorrhage AT helbokraimund earlybraininjuryafterpoorgradesubarachnoidhemorrhage |