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Conformational heterogeneity in human interphase chromosome organization reconciles the FISH and Hi-C paradox
Hi-C experiments are used to infer the contact probabilities between loci separated by varying genome lengths. Contact probability should decrease as the spatial distance between two loci increases. However, studies comparing Hi-C and FISH data show that in some cases the distance between one pair o...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715811/ https://www.ncbi.nlm.nih.gov/pubmed/31467267 http://dx.doi.org/10.1038/s41467-019-11897-0 |