Squamous cell carcinoma of unknown primary origin in a dog presenting with bone metastasis

A 10-year-old female American Pit Bull dog was diagnosed with metastatic undifferentiated carcinoma of the scapula. Immunohistochemistry showed positive immunoexpression for cytokeratins (AE1/AE3, 34BE12, CK7) and vimentin, confirming squamous cell carcinoma. No evidence of nodules was found in the...

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Detalles Bibliográficos
Autores principales: SIERRA MATIZ, Oscar Rodrigo, VIERA, Rafaela Bortolotti, JARK, Paulo Cesar, DOS ANJOS, Denner Santos, MONTEIRO, Julio Edward Hough, MATSUI, Andresa, VASCONCELOS, Rosemeri de Oliveira, SUEIRO, Felipe Ruiz, CALAZANS, Sabryna Gouveia, TINUCCI-COSTA, Mirela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2019
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715932/
https://www.ncbi.nlm.nih.gov/pubmed/31167982
http://dx.doi.org/10.1292/jvms.18-0594
Descripción
Sumario:A 10-year-old female American Pit Bull dog was diagnosed with metastatic undifferentiated carcinoma of the scapula. Immunohistochemistry showed positive immunoexpression for cytokeratins (AE1/AE3, 34BE12, CK7) and vimentin, confirming squamous cell carcinoma. No evidence of nodules was found in the complete physical examination and imaging procedures conducted. The patient was diagnosed with carcinoma of unknown primary origin. Amputation and adjuvant chemotherapy with doxorubicin and piroxicam were performed, but the patient died of respiratory failure after 737 days of diagnosis. Necropsy confirmed undifferentiated carcinoma infiltrating the lungs and kidneys, and showing the same immunoexpression as the tumor in the scapula. Amputation associated with chemotherapy extended the overall survival time of this patient.

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