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Selection Pressures on RNA Sequences and Structures

With the discovery of increasingly more functional noncoding RNAs (ncRNAs), it becomes eminent to more strongly consider them as important players during species evolution. Although tests for negative selection of ncRNAs already exist since the beginning of this century, the SSS-test is the first on...

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Autores principales: Nowick, Katja, Walter Costa, Maria Beatriz, Höner zu Siederdissen, Christian, Stadler, Peter F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6716170/
https://www.ncbi.nlm.nih.gov/pubmed/31496634
http://dx.doi.org/10.1177/1176934319871919
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author Nowick, Katja
Walter Costa, Maria Beatriz
Höner zu Siederdissen, Christian
Stadler, Peter F
author_facet Nowick, Katja
Walter Costa, Maria Beatriz
Höner zu Siederdissen, Christian
Stadler, Peter F
author_sort Nowick, Katja
collection PubMed
description With the discovery of increasingly more functional noncoding RNAs (ncRNAs), it becomes eminent to more strongly consider them as important players during species evolution. Although tests for negative selection of ncRNAs already exist since the beginning of this century, the SSS-test is the first one for also investigating positive selection. When analyzing selection in ncRNAs, it should be taken into account that selection pressures can independently act on sequence and structure. We applied the SSS-test to explore the evolution of ncRNAs in primates and identified more than 100 long noncoding RNAs (lncRNAs) that might evolve under positive selection in humans. With this test, it is now possible to more thoroughly include ncRNAs into evolutionary studies.
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spelling pubmed-67161702019-09-06 Selection Pressures on RNA Sequences and Structures Nowick, Katja Walter Costa, Maria Beatriz Höner zu Siederdissen, Christian Stadler, Peter F Evol Bioinform Online Commentary With the discovery of increasingly more functional noncoding RNAs (ncRNAs), it becomes eminent to more strongly consider them as important players during species evolution. Although tests for negative selection of ncRNAs already exist since the beginning of this century, the SSS-test is the first one for also investigating positive selection. When analyzing selection in ncRNAs, it should be taken into account that selection pressures can independently act on sequence and structure. We applied the SSS-test to explore the evolution of ncRNAs in primates and identified more than 100 long noncoding RNAs (lncRNAs) that might evolve under positive selection in humans. With this test, it is now possible to more thoroughly include ncRNAs into evolutionary studies. SAGE Publications 2019-08-29 /pmc/articles/PMC6716170/ /pubmed/31496634 http://dx.doi.org/10.1177/1176934319871919 Text en © The Author(s) 2019 http://www.creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Commentary
Nowick, Katja
Walter Costa, Maria Beatriz
Höner zu Siederdissen, Christian
Stadler, Peter F
Selection Pressures on RNA Sequences and Structures
title Selection Pressures on RNA Sequences and Structures
title_full Selection Pressures on RNA Sequences and Structures
title_fullStr Selection Pressures on RNA Sequences and Structures
title_full_unstemmed Selection Pressures on RNA Sequences and Structures
title_short Selection Pressures on RNA Sequences and Structures
title_sort selection pressures on rna sequences and structures
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6716170/
https://www.ncbi.nlm.nih.gov/pubmed/31496634
http://dx.doi.org/10.1177/1176934319871919
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