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Antitumor activity of enzymatically hydrolyzed Ganoderma lucidum polysaccharide on U14 cervical carcinoma–bearing mice
Polysaccharides from Ganoderma lucidum have been demonstrated to possess diverse biological activities. Despite lots of studies on the biological activities of Ganoderma lucidum polysaccharide (GLP), little is known regarding the medicinal potential of low–molecular weight enzymatically hydrolyzed G...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6716173/ https://www.ncbi.nlm.nih.gov/pubmed/31462112 http://dx.doi.org/10.1177/2058738419869489 |
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author | Kong, Min Yao, Yao Zhang, Hongmei |
author_facet | Kong, Min Yao, Yao Zhang, Hongmei |
author_sort | Kong, Min |
collection | PubMed |
description | Polysaccharides from Ganoderma lucidum have been demonstrated to possess diverse biological activities. Despite lots of studies on the biological activities of Ganoderma lucidum polysaccharide (GLP), little is known regarding the medicinal potential of low–molecular weight enzymatically hydrolyzed Ganoderma lucidum polysaccharide (EGLP). EGLP was prepared by enzymatic degradation and its potential effects in U14 cervical tumor–bearing mice were evaluated. Both GLP and EGLP delayed tumor growth of the tumor xenograft. The EGLP was superior to native polysaccharide. Moreover, EGLP treatment could effectively protect the immune organs of U14 cervical carcinoma–bearing mice. In addition, the EGLP treatment ameliorated oxidative stress as compared with cyclophosphamide (CTX). Compared with the MC group, the expression of Bcl-2 and COX-2 was obviously decreased by EGLP treatment, whereas the expression of Bax and cleaved caspase-3 was obviously increased. These results indicated that EGLP showed stronger antitumor activity with lower toxic effects and had the potential to be a novel antitumor agent. |
format | Online Article Text |
id | pubmed-6716173 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-67161732019-09-06 Antitumor activity of enzymatically hydrolyzed Ganoderma lucidum polysaccharide on U14 cervical carcinoma–bearing mice Kong, Min Yao, Yao Zhang, Hongmei Int J Immunopathol Pharmacol Letter to the Editor Polysaccharides from Ganoderma lucidum have been demonstrated to possess diverse biological activities. Despite lots of studies on the biological activities of Ganoderma lucidum polysaccharide (GLP), little is known regarding the medicinal potential of low–molecular weight enzymatically hydrolyzed Ganoderma lucidum polysaccharide (EGLP). EGLP was prepared by enzymatic degradation and its potential effects in U14 cervical tumor–bearing mice were evaluated. Both GLP and EGLP delayed tumor growth of the tumor xenograft. The EGLP was superior to native polysaccharide. Moreover, EGLP treatment could effectively protect the immune organs of U14 cervical carcinoma–bearing mice. In addition, the EGLP treatment ameliorated oxidative stress as compared with cyclophosphamide (CTX). Compared with the MC group, the expression of Bcl-2 and COX-2 was obviously decreased by EGLP treatment, whereas the expression of Bax and cleaved caspase-3 was obviously increased. These results indicated that EGLP showed stronger antitumor activity with lower toxic effects and had the potential to be a novel antitumor agent. SAGE Publications 2019-08-28 /pmc/articles/PMC6716173/ /pubmed/31462112 http://dx.doi.org/10.1177/2058738419869489 Text en © The Author(s) 2019 http://www.creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Letter to the Editor Kong, Min Yao, Yao Zhang, Hongmei Antitumor activity of enzymatically hydrolyzed Ganoderma lucidum polysaccharide on U14 cervical carcinoma–bearing mice |
title | Antitumor activity of enzymatically hydrolyzed Ganoderma
lucidum polysaccharide on U14 cervical carcinoma–bearing
mice |
title_full | Antitumor activity of enzymatically hydrolyzed Ganoderma
lucidum polysaccharide on U14 cervical carcinoma–bearing
mice |
title_fullStr | Antitumor activity of enzymatically hydrolyzed Ganoderma
lucidum polysaccharide on U14 cervical carcinoma–bearing
mice |
title_full_unstemmed | Antitumor activity of enzymatically hydrolyzed Ganoderma
lucidum polysaccharide on U14 cervical carcinoma–bearing
mice |
title_short | Antitumor activity of enzymatically hydrolyzed Ganoderma
lucidum polysaccharide on U14 cervical carcinoma–bearing
mice |
title_sort | antitumor activity of enzymatically hydrolyzed ganoderma
lucidum polysaccharide on u14 cervical carcinoma–bearing
mice |
topic | Letter to the Editor |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6716173/ https://www.ncbi.nlm.nih.gov/pubmed/31462112 http://dx.doi.org/10.1177/2058738419869489 |
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