Downregulation of miR-146a Contributes to Cardiac Dysfunction Induced by the Tyrosine Kinase Inhibitor Sunitinib

The main adverse effect of tyrosine kinase inhibitors, such as sunitinib, is cardiac contractile dysfunction; however, the molecular mechanisms of this effect remain largely obscure. MicroRNAs (miRNAs) are key regulatory factors in both cardiovascular diseases and the tyrosine kinase pathway. Theref...

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Detalles Bibliográficos
Autores principales: Shen, Li, Li, Congxin, Zhang, Hua, Qiu, Suhua, Fu, Tian, Xu, Yanfang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6716347/
https://www.ncbi.nlm.nih.gov/pubmed/31507414
http://dx.doi.org/10.3389/fphar.2019.00914

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6716347/
https://www.ncbi.nlm.nih.gov/pubmed/31507414
http://dx.doi.org/10.3389/fphar.2019.00914

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