Neonatal functional brain maturation in the context of perioperative critical care and pain management: A case report

INTRODUCTION: Remarkable plasticity during the first year of life imparts heighted vulnerability of the developing infant brain. Application of resting-state functional magnetic resonance imaging (rs-fMRI) in infants may contribute to our understanding of neuroplastic changes associated with therapeutic interventions and/or brain insults. In addition to showing clinically relevant incidental brain MRI findings, the objective of our pilot study was to test feasibility of rs-fMRI methods at this early age in the context of pediatric perioperative critical care. METHODS: We report the case of a former 33-week premature infant born with long-gap esophageal atresia that underwent complex perioperative critical care (Foker process) requiring prolonged post-operative sedation and whom presented with incidental subdural hematoma. Rs-fMRI data was acquired before (at 1-month corrected age) and after (at 2.25-months corrected age) complex perioperative care. We evaluated resting-state functional connectivity (RSFC) using graph theory to explore the complex structure of brain networks. RESULTS: A transient increase in head circumference coincided temporally with lifting of sedation and initiation of sedation drugs weaning, and qualified for hydrocephalus (93%) but not macrocephaly (>95%). RSFC analysis identified networks spatially consistent with those previously described in the literature, with notable pre-post-treatment qualitative differences in correlated and anticorrelated spontaneous brain activity. DISCUSSION: Current definitions of macrocephaly may require lower threshold criteria for monitoring of critically ill infants. Although we demonstrate that available rs-fMRI could be effectively applied in a critically ill infant in the setting of brain pathology, future group-level studies should investigate RSFC to evaluate maintenance of network homeostasis during development of both healthy and critically ill infants.