Cargando…

Isocitrate Lyase and Succinate Semialdehyde Dehydrogenase Mediate the Synthesis of α-Ketoglutarate in Pseudomonas fluorescens

Glycerol is an important by-product of the biodiesel industry and its transformation into value-added products like keto acids is being actively pursued in order to improve the efficacy of this renewable energy sector. Here, we report that the enhanced production of α-ketoglutarate (KG) effected by...

Descripción completa

Detalles Bibliográficos
Autores principales:	Alhasawi, Azhar A., Thomas, Sean C., Tharmalingam, Sujeethar, Legendre, Felix, Appanna, Vasu D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6716453/ https://www.ncbi.nlm.nih.gov/pubmed/31507554 http://dx.doi.org/10.3389/fmicb.2019.01929

Ejemplares similares

A Metabolic Network Mediating the Cycling of Succinate, a Product of ROS Detoxification into α-Ketoglutarate, an Antioxidant
por: Legendre, Félix, et al.
Publicado: (2022)

α-Ketoglutarate Accumulation Is Not Dependent on Isocitrate Dehydrogenase Activity during Tellurite Detoxification in Escherichia coli
por: Reinoso, Claudia A., et al.
Publicado: (2013)

Succinic Semialdehyde Dehydrogenase Deficiency: An Update
por: Didiasova, Miroslava, et al.
Publicado: (2020)

Succinic semialdehyde dehydrogenase deficiency presenting with central hypothyroidism
por: Alghamdi, Malak Ali, et al.
Publicado: (2020)

Evidence of redox imbalance in a patient with succinic semialdehyde dehydrogenase deficiency
por: Niemi, Anna-Kaisa, et al.
Publicado: (2014)

Sensorineural Hearing Loss in a Child with Succinic Semialdehyde Dehydrogenase Deficiency
por: Parezanović, M, et al.
Publicado: (2023)

GABA, glutamine, glutamate oxidation and succinic semialdehyde dehydrogenase expression in human gliomas
por: Hujber, Zoltán, et al.
Publicado: (2018)

Acute Psychotic Syndrome in a Male Adolescent with Succinic Semialdehyde Dehydrogenase Deficiency
por: Kontoangelos, Konstantinos, et al.
Publicado: (2019)

OCD symptoms in succinic semialdehyde dehydrogenase (SSADH) deficiency: a case report
por: Phakey, Sachin, et al.
Publicado: (2020)

Effect of Salt Stress on the Activity, Expression, and Promoter Methylation of Succinate Dehydrogenase and Succinic Semialdehyde Dehydrogenase in Maize (Zea mays L.) Leaves
por: Fedorin, Dmitry N., et al.
Publicado: (2022)

Kinetic and Structural Characterization for Cofactor Preference of Succinic Semialdehyde Dehydrogenase from Streptococcus pyogenes
por: Jang, Eun Hyuk, et al.
Publicado: (2014)

Clinical diagnosis and mutation analysis of four Chinese families with succinic semialdehyde dehydrogenase deficiency
por: Wang, Ping, et al.
Publicado: (2019)

Cellular and molecular outcomes of glutamine supplementation in the brain of succinic semialdehyde dehydrogenase‐deficient mice
por: Brown, Madalyn N., et al.
Publicado: (2020)

Metabolic Stroke: A Novel Presentation in a Child with Succinic Semialdehyde Dehydrogenase Deficiency
por: Yoganathan, Sangeetha, et al.
Publicado: (2020)

The Metabolic Reprogramming Evoked by Nitrosative Stress Triggers the Anaerobic Utilization of Citrate in Pseudomonas fluorescens
por: Auger, Christopher, et al.
Publicado: (2011)

Kinetic and structural insights into enzymatic mechanism of succinic semialdehyde dehydrogenase from Cyanothece sp. ATCC51142
por: Xie, Congcong, et al.
Publicado: (2020)

Longitudinal metabolomics in dried bloodspots yields profiles informing newborn screening for succinic semialdehyde dehydrogenase deficiency
por: Brown, Madalyn, et al.
Publicado: (2020)

Understanding the Molecular Mechanisms of Succinic Semialdehyde Dehydrogenase Deficiency (SSADHD): Towards the Development of SSADH-Targeted Medicine
por: Lee, Henry H. C., et al.
Publicado: (2022)

Comparative genomics of aldehyde dehydrogenase 5a1 (succinate semialdehyde dehydrogenase) and accumulation of gamma-hydroxybutyrate associated with its deficiency
por: Malaspina, Patrizia, et al.
Publicado: (2009)

An ATP and Oxalate Generating Variant Tricarboxylic Acid Cycle Counters Aluminum Toxicity in Pseudomonas fluorescens
por: Singh, Ranji, et al.
Publicado: (2009)

Dysfunctional mitochondrial bioenergetics and the pathogenesis of hepatic disorders
por: Auger, Christopher, et al.
Publicado: (2015)

Structural characterization of aspartate-semialdehyde dehydrogenase from Pseudomonas aeruginosa and Neisseria gonorrhoeae
por: Teakel, S. L., et al.
Publicado: (2022)

Mutants of GABA Transaminase (POP2) Suppress the Severe Phenotype of succinic semialdehyde dehydrogenase (ssadh) Mutants in Arabidopsis
por: Ludewig, Frank, et al.
Publicado: (2008)

The X-Ray Crystal Structure of Escherichia coli Succinic Semialdehyde Dehydrogenase; Structural Insights into NADP(+)/Enzyme Interactions
por: Langendorf, Christopher G., et al.
Publicado: (2010)

Aberrant GABA(A) Receptor-Mediated Inhibition in Cortico-Thalamic Networks of Succinic Semialdehyde Dehydrogenase Deficient Mice
por: Errington, Adam C., et al.
Publicado: (2011)

In vitro modeling of experimental succinic semialdehyde dehydrogenase deficiency (SSADHD) using brain-derived neural stem cells
por: Vogel, Kara R., et al.
Publicado: (2017)

Metabolome-guided genomics to identify mutations in isocitrate dehydrogenase, fumarate hydratase and succinate dehydrogenase genes in pheochromocytoma and paraganglioma
por: Richter, Susan, et al.
Publicado: (2018)

Heterogeneous multimeric structure of isocitrate lyase in complex with succinate and itaconate provides novel insights into its inhibitory mechanism
por: Kwon, Sunghark, et al.
Publicado: (2021)

Neurotransmitter alterations in embryonic succinate semialdehyde dehydrogenase (SSADH) deficiency suggest a heightened excitatory state during development
por: Jansen, Erwin EW, et al.
Publicado: (2008)

Targeted screening of succinic semialdehyde dehydrogenase deficiency (SSADHD) employing an enzymatic assay for γ-hydroxybutyric acid (GHB) in biofluids
por: Wernli, C., et al.
Publicado: (2016)

Rett syndrome (MECP2) and succinic semialdehyde dehydrogenase (ALDH5A1) deficiency in a developmentally delayed female
por: Brown, Madalyn, et al.
Publicado: (2019)

A Missense Variant in ALDH5A1 Associated with Canine Succinic Semialdehyde Dehydrogenase Deficiency (SSADHD) in the Saluki Dog
por: Vernau, Karen M., et al.
Publicado: (2020)

Novel biomarkers and age-related metabolite correlations in plasma and dried blood spots from patients with succinic semialdehyde dehydrogenase deficiency
por: Kirby, Trevor, et al.
Publicado: (2020)

Syndromic Autism Spectrum Disorder: Let Us Not Forget about Succinic Semialdehyde Dehydrogenase Deficiency. A Case Report with Literature Review
por: Posar, Annio, et al.
Publicado: (2020)

Evaluation on the responses of succinate dehydrogenase, isocitrate dehydrogenase, malate dehydrogenase and glucose-6-phosphate dehydrogenase to acid shock generated acid tolerance in Escherichia coli
por: Jain, Pradeep Kumar, et al.
Publicado: (2013)

Human iPSC-derived neural stem cells with ALDH5A1 mutation as a model of succinic semialdehyde dehydrogenase deficiency
por: Chen, Xiaodan, et al.
Publicado: (2022)

Demystifying the catalytic pathway of Mycobacterium tuberculosis isocitrate lyase
por: Ibeji, Collins U., et al.
Publicado: (2020)

Identification of Pseudomonas fluorescens Chemotaxis Sensory Proteins for Malate, Succinate, and Fumarate, and Their Involvement in Root Colonization
por: Oku, Shota, et al.
Publicado: (2014)

Immobilization of the Aspartate Ammonia‐Lyase from Pseudomonas fluorescens R124 on Magnetic Nanoparticles: Characterization and Kinetics
por: Csuka, Pál, et al.
Publicado: (2022)

Succinic Semialdehyde Dehydrogenase Deficiency: In Vitro and In Silico Characterization of a Novel Pathogenic Missense Variant and Analysis of the Mutational Spectrum of ALDH5A1
por: Brennenstuhl, Heiko, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_mag9d9oklpmudchv6m27p8v8dj