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Peptide-Based Functional Biomaterials for Soft-Tissue Repair

Synthetically derived peptide-based biomaterials are in many instances capable of mimicking the structure and function of their full-length endogenous counterparts. Combine this with the fact that short mimetic peptides are easier to produce when compared to full length proteins, show enhanced proce...

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Detalles Bibliográficos
Autores principales: Hosoyama, Katsuhiro, Lazurko, Caitlin, Muñoz, Marcelo, McTiernan, Christopher D., Alarcon, Emilio I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6716508/
https://www.ncbi.nlm.nih.gov/pubmed/31508416
http://dx.doi.org/10.3389/fbioe.2019.00205
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author Hosoyama, Katsuhiro
Lazurko, Caitlin
Muñoz, Marcelo
McTiernan, Christopher D.
Alarcon, Emilio I.
author_facet Hosoyama, Katsuhiro
Lazurko, Caitlin
Muñoz, Marcelo
McTiernan, Christopher D.
Alarcon, Emilio I.
author_sort Hosoyama, Katsuhiro
collection PubMed
description Synthetically derived peptide-based biomaterials are in many instances capable of mimicking the structure and function of their full-length endogenous counterparts. Combine this with the fact that short mimetic peptides are easier to produce when compared to full length proteins, show enhanced processability and ease of modification, and have the ability to be prepared under well-defined and controlled conditions; it becomes obvious why there has been a recent push to develop regenerative biomaterials from these molecules. There is increasing evidence that the incorporation of peptides within regenerative scaffolds can result in the generation of structural recognition motifs that can enhance cell attachment or induce cell signaling pathways, improving cell infiltration or promote a variety of other modulatory biochemical responses. By highlighting the current approaches in the design and application of short mimetic peptides, we hope to demonstrate their potential in soft-tissue healing while at the same time drawing attention to the advances made to date and the problems which need to be overcome to advance these materials to the clinic for applications in heart, skin, and cornea repair.
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spelling pubmed-67165082019-09-10 Peptide-Based Functional Biomaterials for Soft-Tissue Repair Hosoyama, Katsuhiro Lazurko, Caitlin Muñoz, Marcelo McTiernan, Christopher D. Alarcon, Emilio I. Front Bioeng Biotechnol Bioengineering and Biotechnology Synthetically derived peptide-based biomaterials are in many instances capable of mimicking the structure and function of their full-length endogenous counterparts. Combine this with the fact that short mimetic peptides are easier to produce when compared to full length proteins, show enhanced processability and ease of modification, and have the ability to be prepared under well-defined and controlled conditions; it becomes obvious why there has been a recent push to develop regenerative biomaterials from these molecules. There is increasing evidence that the incorporation of peptides within regenerative scaffolds can result in the generation of structural recognition motifs that can enhance cell attachment or induce cell signaling pathways, improving cell infiltration or promote a variety of other modulatory biochemical responses. By highlighting the current approaches in the design and application of short mimetic peptides, we hope to demonstrate their potential in soft-tissue healing while at the same time drawing attention to the advances made to date and the problems which need to be overcome to advance these materials to the clinic for applications in heart, skin, and cornea repair. Frontiers Media S.A. 2019-08-23 /pmc/articles/PMC6716508/ /pubmed/31508416 http://dx.doi.org/10.3389/fbioe.2019.00205 Text en Copyright © 2019 Hosoyama, Lazurko, Muñoz, McTiernan and Alarcon. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Hosoyama, Katsuhiro
Lazurko, Caitlin
Muñoz, Marcelo
McTiernan, Christopher D.
Alarcon, Emilio I.
Peptide-Based Functional Biomaterials for Soft-Tissue Repair
title Peptide-Based Functional Biomaterials for Soft-Tissue Repair
title_full Peptide-Based Functional Biomaterials for Soft-Tissue Repair
title_fullStr Peptide-Based Functional Biomaterials for Soft-Tissue Repair
title_full_unstemmed Peptide-Based Functional Biomaterials for Soft-Tissue Repair
title_short Peptide-Based Functional Biomaterials for Soft-Tissue Repair
title_sort peptide-based functional biomaterials for soft-tissue repair
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6716508/
https://www.ncbi.nlm.nih.gov/pubmed/31508416
http://dx.doi.org/10.3389/fbioe.2019.00205
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