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Clinical improvement following vitamin D3 supplementation in children with chronic tic disorders
PURPOSE: Vitamin D deficiency has been found in children with chronic tic disorders (CTDs). Our previous data showed that serum 25-hydroxyvitamin D [25(OH)D] level in children with CTDs was lower than that of the healthy controls and lower serum 25(OH)D level was associated with increased severity o...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6716592/ https://www.ncbi.nlm.nih.gov/pubmed/31933522 http://dx.doi.org/10.2147/NDT.S212322 |
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author | Li, Hong-Hua Xu, Zhi-Da Wang, Bing Feng, Jun-Yan Dong, Han-Yu Jia, Fei-Yong |
author_facet | Li, Hong-Hua Xu, Zhi-Da Wang, Bing Feng, Jun-Yan Dong, Han-Yu Jia, Fei-Yong |
author_sort | Li, Hong-Hua |
collection | PubMed |
description | PURPOSE: Vitamin D deficiency has been found in children with chronic tic disorders (CTDs). Our previous data showed that serum 25-hydroxyvitamin D [25(OH)D] level in children with CTDs was lower than that of the healthy controls and lower serum 25(OH)D level was associated with increased severity of the tic disorder. Thus, we intend to further verify this phenomenon and examine the effect of vitamin D3 on CTDs. PATIENTS AND METHODS: In total, 120 children with CTDs and 140 normal controls were enrolled in this study, with 36/120 of those in the CTD group receiving vitamin D3 treatment for 3 months. The Yale Global Tic Severity Scale (YGTSS) and Clinical Global Impression of Severity of Illness (CGI-SI) were, respectively, used to evaluate the tic severity. High-performance liquid chromatography and tandem mass spectrometry were used to measure serum 25(OH)D level. RESULTS: Those children with CTDs exhibited significantly lower 25(OH)D levels than did healthy controls, and these reduced 25(OH)D levels were linked to increasing severity of tic symptoms. After treatment with supplemental vitamin D3, serum 25(OH)D level and scores of YGTSS total, motor tics, phonic tics, total tic, impairment, and CGI-SI improved significantly in children with CTDs without any adverse reactions. CONCLUSION: Supplementation vitamin D3, given its low cost and excellent safety, may be an effective means of improving symptoms in certain children with CTDs. |
format | Online Article Text |
id | pubmed-6716592 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-67165922020-01-13 Clinical improvement following vitamin D3 supplementation in children with chronic tic disorders Li, Hong-Hua Xu, Zhi-Da Wang, Bing Feng, Jun-Yan Dong, Han-Yu Jia, Fei-Yong Neuropsychiatr Dis Treat Original Research PURPOSE: Vitamin D deficiency has been found in children with chronic tic disorders (CTDs). Our previous data showed that serum 25-hydroxyvitamin D [25(OH)D] level in children with CTDs was lower than that of the healthy controls and lower serum 25(OH)D level was associated with increased severity of the tic disorder. Thus, we intend to further verify this phenomenon and examine the effect of vitamin D3 on CTDs. PATIENTS AND METHODS: In total, 120 children with CTDs and 140 normal controls were enrolled in this study, with 36/120 of those in the CTD group receiving vitamin D3 treatment for 3 months. The Yale Global Tic Severity Scale (YGTSS) and Clinical Global Impression of Severity of Illness (CGI-SI) were, respectively, used to evaluate the tic severity. High-performance liquid chromatography and tandem mass spectrometry were used to measure serum 25(OH)D level. RESULTS: Those children with CTDs exhibited significantly lower 25(OH)D levels than did healthy controls, and these reduced 25(OH)D levels were linked to increasing severity of tic symptoms. After treatment with supplemental vitamin D3, serum 25(OH)D level and scores of YGTSS total, motor tics, phonic tics, total tic, impairment, and CGI-SI improved significantly in children with CTDs without any adverse reactions. CONCLUSION: Supplementation vitamin D3, given its low cost and excellent safety, may be an effective means of improving symptoms in certain children with CTDs. Dove 2019-08-26 /pmc/articles/PMC6716592/ /pubmed/31933522 http://dx.doi.org/10.2147/NDT.S212322 Text en © 2019 Li et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Li, Hong-Hua Xu, Zhi-Da Wang, Bing Feng, Jun-Yan Dong, Han-Yu Jia, Fei-Yong Clinical improvement following vitamin D3 supplementation in children with chronic tic disorders |
title | Clinical improvement following vitamin D3 supplementation in children with chronic tic disorders |
title_full | Clinical improvement following vitamin D3 supplementation in children with chronic tic disorders |
title_fullStr | Clinical improvement following vitamin D3 supplementation in children with chronic tic disorders |
title_full_unstemmed | Clinical improvement following vitamin D3 supplementation in children with chronic tic disorders |
title_short | Clinical improvement following vitamin D3 supplementation in children with chronic tic disorders |
title_sort | clinical improvement following vitamin d3 supplementation in children with chronic tic disorders |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6716592/ https://www.ncbi.nlm.nih.gov/pubmed/31933522 http://dx.doi.org/10.2147/NDT.S212322 |
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