Association between the persistent organic pollutants and polycystic ovary syndrome: A protocol for a systematic review and meta-analysis

BACKGROUND: Current evidence concerning the association between persistent organic pollutants (POPs) and polycystic ovary syndrome (PCOS) is inconsistent. The aim of the present systematic review and meta-analysis is to evaluate the role of POPs in PCOS. METHODS: Databases including PubMed, Embase, Web of Science, and CNKI will be searched to identify qualified studies. All qualified studies regarding the association between POPs and PCOS will be included. The primary outcome of the present study is POPs levels in serum of subjects. Pooled analysis with corresponding 95% confidence intervals will be performed. RESULTS: The comprehensive analysis and quantitative assessment will provide a better understanding of POPs concentrations in patients with PCOS. CONCLUSION: This meta-analysis and systematic review will generate evidence of the association between POPs and PCOS. PROSPERO REGISTRATION NUMBER: PROSPERO CRD42019126373