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Efficacy and safety of Chinese medicines for asthma: A systematic review protocol

BACKGROUND: Asthma is a complex disease associated with many factors such as immunologic, environmental, genetic, and other factors. Common medicines used to treat asthma include β-agonist and glucocorticoid. However, in the long-term treatment, the effect of the above-mentioned drugs is not satisfa...

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Autores principales: Shi, Qi, Si, Dongxu, Bao, Haipeng, Yan, Yue, Kong, Yanhua, Li, Chunlei, He, Wenfeng, Damchaaperenlei, Dashzeveg, Yu, Mingxia, Li, Youlin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6716730/
https://www.ncbi.nlm.nih.gov/pubmed/31441897
http://dx.doi.org/10.1097/MD.0000000000016958
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author Shi, Qi
Si, Dongxu
Bao, Haipeng
Yan, Yue
Kong, Yanhua
Li, Chunlei
He, Wenfeng
Damchaaperenlei, Dashzeveg
Yu, Mingxia
Li, Youlin
author_facet Shi, Qi
Si, Dongxu
Bao, Haipeng
Yan, Yue
Kong, Yanhua
Li, Chunlei
He, Wenfeng
Damchaaperenlei, Dashzeveg
Yu, Mingxia
Li, Youlin
author_sort Shi, Qi
collection PubMed
description BACKGROUND: Asthma is a complex disease associated with many factors such as immunologic, environmental, genetic, and other factors. Common medicines used to treat asthma include β-agonist and glucocorticoid. However, in the long-term treatment, the effect of the above-mentioned drugs is not satisfactory, so many patients choose oral Chinese medicines instead of western medicines. The introduction of Chinese medicines therapies, a rapid proliferation of the literature on management of asthma in general, call for novel ways of evidence synthesis in this area. This systematic review is to systematically summarize and evaluate a large number of evidences for Chinese herbal interventions for asthma. Evaluate the efficacy and safety of Chinese medicines in the treatment of asthma and inform a decision aid for the clinical encounter between patients and clinicians. In addition, it helps to establish a future research agenda. METHODS: Five English databases (PubMed, Web of science, EBASE, Springer Cochrane Library, and WHO International Clinical Trials Registry Platform) and 4 Chinese databases (Wanfang Database, Chinese Scientific Journal Database, China National Knowledge Infrastructure Database, and Chinese Biomedical Literature Database) will be searched normatively according to the rule of each database from the inception to the present. The literature screening, data extraction, and quality assessment will be conducted by 2 researchers independently. Data will be synthesized by either the fixed-effects or random-effects model according to a heterogeneity test. Asthma control test symptom score will be assessed as the primary outcome. The curative effect of single symptom and sign; Withdrawal and reduction of western medicines in a course of treatment, including: time, type, and quantity; Maintenance of western medicines after the course of treatment, including: type, quantity; Asthma Quality of Life Questionnaire; laboratory efficacy indexes as the secondary outcome. General physical examination; routine examination of blood, urine, and stool; electrocardiogram; liver and kidney function examination; possible adverse reactions and related detection indicators as the security indexes. Meta-analysis will be performed using RevMan5.3.5 software provided by the Cochrane Collaboration. RESULTS: This study will provide high-quality synthesis based on current evidence of Chinese medicines treatment for asthma in several aspects, including asthma control score, side effects and laboratory examination such as lung-function test, serum total immunoglobulin, and so on. CONCLUSION: The results of this study will provide updated evidence for whether Chinese medicines is an effective and safe intervention for asthma. PROSPERO REGISTRATION NUMBER: PROSPERO CRD42019136074.
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spelling pubmed-67167302019-10-01 Efficacy and safety of Chinese medicines for asthma: A systematic review protocol Shi, Qi Si, Dongxu Bao, Haipeng Yan, Yue Kong, Yanhua Li, Chunlei He, Wenfeng Damchaaperenlei, Dashzeveg Yu, Mingxia Li, Youlin Medicine (Baltimore) 6700 BACKGROUND: Asthma is a complex disease associated with many factors such as immunologic, environmental, genetic, and other factors. Common medicines used to treat asthma include β-agonist and glucocorticoid. However, in the long-term treatment, the effect of the above-mentioned drugs is not satisfactory, so many patients choose oral Chinese medicines instead of western medicines. The introduction of Chinese medicines therapies, a rapid proliferation of the literature on management of asthma in general, call for novel ways of evidence synthesis in this area. This systematic review is to systematically summarize and evaluate a large number of evidences for Chinese herbal interventions for asthma. Evaluate the efficacy and safety of Chinese medicines in the treatment of asthma and inform a decision aid for the clinical encounter between patients and clinicians. In addition, it helps to establish a future research agenda. METHODS: Five English databases (PubMed, Web of science, EBASE, Springer Cochrane Library, and WHO International Clinical Trials Registry Platform) and 4 Chinese databases (Wanfang Database, Chinese Scientific Journal Database, China National Knowledge Infrastructure Database, and Chinese Biomedical Literature Database) will be searched normatively according to the rule of each database from the inception to the present. The literature screening, data extraction, and quality assessment will be conducted by 2 researchers independently. Data will be synthesized by either the fixed-effects or random-effects model according to a heterogeneity test. Asthma control test symptom score will be assessed as the primary outcome. The curative effect of single symptom and sign; Withdrawal and reduction of western medicines in a course of treatment, including: time, type, and quantity; Maintenance of western medicines after the course of treatment, including: type, quantity; Asthma Quality of Life Questionnaire; laboratory efficacy indexes as the secondary outcome. General physical examination; routine examination of blood, urine, and stool; electrocardiogram; liver and kidney function examination; possible adverse reactions and related detection indicators as the security indexes. Meta-analysis will be performed using RevMan5.3.5 software provided by the Cochrane Collaboration. RESULTS: This study will provide high-quality synthesis based on current evidence of Chinese medicines treatment for asthma in several aspects, including asthma control score, side effects and laboratory examination such as lung-function test, serum total immunoglobulin, and so on. CONCLUSION: The results of this study will provide updated evidence for whether Chinese medicines is an effective and safe intervention for asthma. PROSPERO REGISTRATION NUMBER: PROSPERO CRD42019136074. Wolters Kluwer Health 2019-08-23 /pmc/articles/PMC6716730/ /pubmed/31441897 http://dx.doi.org/10.1097/MD.0000000000016958 Text en Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle 6700
Shi, Qi
Si, Dongxu
Bao, Haipeng
Yan, Yue
Kong, Yanhua
Li, Chunlei
He, Wenfeng
Damchaaperenlei, Dashzeveg
Yu, Mingxia
Li, Youlin
Efficacy and safety of Chinese medicines for asthma: A systematic review protocol
title Efficacy and safety of Chinese medicines for asthma: A systematic review protocol
title_full Efficacy and safety of Chinese medicines for asthma: A systematic review protocol
title_fullStr Efficacy and safety of Chinese medicines for asthma: A systematic review protocol
title_full_unstemmed Efficacy and safety of Chinese medicines for asthma: A systematic review protocol
title_short Efficacy and safety of Chinese medicines for asthma: A systematic review protocol
title_sort efficacy and safety of chinese medicines for asthma: a systematic review protocol
topic 6700
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6716730/
https://www.ncbi.nlm.nih.gov/pubmed/31441897
http://dx.doi.org/10.1097/MD.0000000000016958
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