Macro-aspartate Aminotransferase: Misleading Finding in a Patient with Non-alcoholic Fatty Liver Disease

Persistent elevation of aspartate aminotransferase (AST) activity in serum due to the presence of a macro-enzyme form of AST (macro-AST) may lead to diagnostic confusion in many clinical conditions, particularly in those associated with chronic liver disease. We present a case of macro-AST in a pati...

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Detalles Bibliográficos
Autores principales: Sharma, Neha, Darr, Umar, Darr, Amir, Sood, Gagan K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2019
Materias:
Endocrinology/Diabetes/Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6716764/
https://www.ncbi.nlm.nih.gov/pubmed/31497458
http://dx.doi.org/10.7759/cureus.5042
Descripción
Sumario:Persistent elevation of aspartate aminotransferase (AST) activity in serum due to the presence of a macro-enzyme form of AST (macro-AST) may lead to diagnostic confusion in many clinical conditions, particularly in those associated with chronic liver disease. We present a case of macro-AST in a patient with non-alcoholic fatty liver disease in which polyethylene glycol precipitation confirmed the cause of disproportionately elevated AST as macro-AST.

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