Macro-aspartate Aminotransferase: Misleading Finding in a Patient with Non-alcoholic Fatty Liver Disease

Persistent elevation of aspartate aminotransferase (AST) activity in serum due to the presence of a macro-enzyme form of AST (macro-AST) may lead to diagnostic confusion in many clinical conditions, particularly in those associated with chronic liver disease. We present a case of macro-AST in a pati...

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Detalles Bibliográficos
Autores principales: Sharma, Neha, Darr, Umar, Darr, Amir, Sood, Gagan K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2019
Materias:
Endocrinology/Diabetes/Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6716764/
https://www.ncbi.nlm.nih.gov/pubmed/31497458
http://dx.doi.org/10.7759/cureus.5042
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author Sharma, Neha
Darr, Umar
Darr, Amir
Sood, Gagan K
author_facet Sharma, Neha
Darr, Umar
Darr, Amir
Sood, Gagan K
author_sort Sharma, Neha
collection PubMed
description Persistent elevation of aspartate aminotransferase (AST) activity in serum due to the presence of a macro-enzyme form of AST (macro-AST) may lead to diagnostic confusion in many clinical conditions, particularly in those associated with chronic liver disease. We present a case of macro-AST in a patient with non-alcoholic fatty liver disease in which polyethylene glycol precipitation confirmed the cause of disproportionately elevated AST as macro-AST.
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spelling pubmed-67167642019-09-06 Macro-aspartate Aminotransferase: Misleading Finding in a Patient with Non-alcoholic Fatty Liver Disease Sharma, Neha Darr, Umar Darr, Amir Sood, Gagan K Cureus Endocrinology/Diabetes/Metabolism Persistent elevation of aspartate aminotransferase (AST) activity in serum due to the presence of a macro-enzyme form of AST (macro-AST) may lead to diagnostic confusion in many clinical conditions, particularly in those associated with chronic liver disease. We present a case of macro-AST in a patient with non-alcoholic fatty liver disease in which polyethylene glycol precipitation confirmed the cause of disproportionately elevated AST as macro-AST. Cureus 2019-06-29 /pmc/articles/PMC6716764/ /pubmed/31497458 http://dx.doi.org/10.7759/cureus.5042 Text en Copyright © 2019, Sharma et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Endocrinology/Diabetes/Metabolism
Sharma, Neha
Darr, Umar
Darr, Amir
Sood, Gagan K
Macro-aspartate Aminotransferase: Misleading Finding in a Patient with Non-alcoholic Fatty Liver Disease
title Macro-aspartate Aminotransferase: Misleading Finding in a Patient with Non-alcoholic Fatty Liver Disease
title_full Macro-aspartate Aminotransferase: Misleading Finding in a Patient with Non-alcoholic Fatty Liver Disease
title_fullStr Macro-aspartate Aminotransferase: Misleading Finding in a Patient with Non-alcoholic Fatty Liver Disease
title_full_unstemmed Macro-aspartate Aminotransferase: Misleading Finding in a Patient with Non-alcoholic Fatty Liver Disease
title_short Macro-aspartate Aminotransferase: Misleading Finding in a Patient with Non-alcoholic Fatty Liver Disease
title_sort macro-aspartate aminotransferase: misleading finding in a patient with non-alcoholic fatty liver disease
topic Endocrinology/Diabetes/Metabolism
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6716764/
https://www.ncbi.nlm.nih.gov/pubmed/31497458
http://dx.doi.org/10.7759/cureus.5042
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AT darramir macroaspartateaminotransferasemisleadingfindinginapatientwithnonalcoholicfattyliverdisease
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