Agonist-induced membrane nanodomain clustering drives GLP-1 receptor responses in pancreatic beta cells

The glucagon-like peptide-1 receptor (GLP-1R), a key pharmacological target in type 2 diabetes (T2D) and obesity, undergoes rapid endocytosis after stimulation by endogenous and therapeutic agonists. We have previously highlighted the relevance of this process in fine-tuning GLP-1R responses in panc...

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Detalles Bibliográficos
Autores principales: Buenaventura, Teresa, Bitsi, Stavroula, Laughlin, William E., Burgoyne, Thomas, Lyu, Zekun, Oqua, Affiong I., Norman, Hannah, McGlone, Emma R., Klymchenko, Andrey S., Corrêa, Ivan R., Walker, Abigail, Inoue, Asuka, Hanyaloglu, Aylin, Grimes, Jak, Koszegi, Zsombor, Calebiro, Davide, Rutter, Guy A., Bloom, Stephen R., Jones, Ben, Tomas, Alejandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6716783/
https://www.ncbi.nlm.nih.gov/pubmed/31430273
http://dx.doi.org/10.1371/journal.pbio.3000097

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