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Repair of tooth enamel by a biomimetic mineralization frontier ensuring epitaxial growth
The regeneration of tooth enamel, the hardest biological tissue, remains a considerable challenge because its complicated and well-aligned apatite structure has not been duplicated artificially. We herein reveal that a rationally designed material composed of calcium phosphate ion clusters can be us...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6716959/ https://www.ncbi.nlm.nih.gov/pubmed/31497647 http://dx.doi.org/10.1126/sciadv.aaw9569 |
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author | Shao, Changyu Jin, Biao Mu, Zhao Lu, Hao Zhao, Yueqi Wu, Zhifang Yan, Lumiao Zhang, Zhisen Zhou, Yanchun Pan, Haihua Liu, Zhaoming Tang, Ruikang |
author_facet | Shao, Changyu Jin, Biao Mu, Zhao Lu, Hao Zhao, Yueqi Wu, Zhifang Yan, Lumiao Zhang, Zhisen Zhou, Yanchun Pan, Haihua Liu, Zhaoming Tang, Ruikang |
author_sort | Shao, Changyu |
collection | PubMed |
description | The regeneration of tooth enamel, the hardest biological tissue, remains a considerable challenge because its complicated and well-aligned apatite structure has not been duplicated artificially. We herein reveal that a rationally designed material composed of calcium phosphate ion clusters can be used to produce a precursor layer to induce the epitaxial crystal growth of enamel apatite, which mimics the biomineralization crystalline-amorphous frontier of hard tissue development in nature. After repair, the damaged enamel can be recovered completely because its hierarchical structure and mechanical properties are identical to those of natural enamel. The suggested phase transformation–based epitaxial growth follows a promising strategy for enamel regeneration and, more generally, for biomimetic reproduction of materials with complicated structure. |
format | Online Article Text |
id | pubmed-6716959 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | American Association for the Advancement of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-67169592019-09-06 Repair of tooth enamel by a biomimetic mineralization frontier ensuring epitaxial growth Shao, Changyu Jin, Biao Mu, Zhao Lu, Hao Zhao, Yueqi Wu, Zhifang Yan, Lumiao Zhang, Zhisen Zhou, Yanchun Pan, Haihua Liu, Zhaoming Tang, Ruikang Sci Adv Research Articles The regeneration of tooth enamel, the hardest biological tissue, remains a considerable challenge because its complicated and well-aligned apatite structure has not been duplicated artificially. We herein reveal that a rationally designed material composed of calcium phosphate ion clusters can be used to produce a precursor layer to induce the epitaxial crystal growth of enamel apatite, which mimics the biomineralization crystalline-amorphous frontier of hard tissue development in nature. After repair, the damaged enamel can be recovered completely because its hierarchical structure and mechanical properties are identical to those of natural enamel. The suggested phase transformation–based epitaxial growth follows a promising strategy for enamel regeneration and, more generally, for biomimetic reproduction of materials with complicated structure. American Association for the Advancement of Science 2019-08-30 /pmc/articles/PMC6716959/ /pubmed/31497647 http://dx.doi.org/10.1126/sciadv.aaw9569 Text en Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (http://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited. |
spellingShingle | Research Articles Shao, Changyu Jin, Biao Mu, Zhao Lu, Hao Zhao, Yueqi Wu, Zhifang Yan, Lumiao Zhang, Zhisen Zhou, Yanchun Pan, Haihua Liu, Zhaoming Tang, Ruikang Repair of tooth enamel by a biomimetic mineralization frontier ensuring epitaxial growth |
title | Repair of tooth enamel by a biomimetic mineralization frontier ensuring epitaxial growth |
title_full | Repair of tooth enamel by a biomimetic mineralization frontier ensuring epitaxial growth |
title_fullStr | Repair of tooth enamel by a biomimetic mineralization frontier ensuring epitaxial growth |
title_full_unstemmed | Repair of tooth enamel by a biomimetic mineralization frontier ensuring epitaxial growth |
title_short | Repair of tooth enamel by a biomimetic mineralization frontier ensuring epitaxial growth |
title_sort | repair of tooth enamel by a biomimetic mineralization frontier ensuring epitaxial growth |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6716959/ https://www.ncbi.nlm.nih.gov/pubmed/31497647 http://dx.doi.org/10.1126/sciadv.aaw9569 |
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