Cargando…

Repair of tooth enamel by a biomimetic mineralization frontier ensuring epitaxial growth

The regeneration of tooth enamel, the hardest biological tissue, remains a considerable challenge because its complicated and well-aligned apatite structure has not been duplicated artificially. We herein reveal that a rationally designed material composed of calcium phosphate ion clusters can be us...

Descripción completa

Detalles Bibliográficos
Autores principales: Shao, Changyu, Jin, Biao, Mu, Zhao, Lu, Hao, Zhao, Yueqi, Wu, Zhifang, Yan, Lumiao, Zhang, Zhisen, Zhou, Yanchun, Pan, Haihua, Liu, Zhaoming, Tang, Ruikang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6716959/
https://www.ncbi.nlm.nih.gov/pubmed/31497647
http://dx.doi.org/10.1126/sciadv.aaw9569
_version_ 1783447479218339840
author Shao, Changyu
Jin, Biao
Mu, Zhao
Lu, Hao
Zhao, Yueqi
Wu, Zhifang
Yan, Lumiao
Zhang, Zhisen
Zhou, Yanchun
Pan, Haihua
Liu, Zhaoming
Tang, Ruikang
author_facet Shao, Changyu
Jin, Biao
Mu, Zhao
Lu, Hao
Zhao, Yueqi
Wu, Zhifang
Yan, Lumiao
Zhang, Zhisen
Zhou, Yanchun
Pan, Haihua
Liu, Zhaoming
Tang, Ruikang
author_sort Shao, Changyu
collection PubMed
description The regeneration of tooth enamel, the hardest biological tissue, remains a considerable challenge because its complicated and well-aligned apatite structure has not been duplicated artificially. We herein reveal that a rationally designed material composed of calcium phosphate ion clusters can be used to produce a precursor layer to induce the epitaxial crystal growth of enamel apatite, which mimics the biomineralization crystalline-amorphous frontier of hard tissue development in nature. After repair, the damaged enamel can be recovered completely because its hierarchical structure and mechanical properties are identical to those of natural enamel. The suggested phase transformation–based epitaxial growth follows a promising strategy for enamel regeneration and, more generally, for biomimetic reproduction of materials with complicated structure.
format Online
Article
Text
id pubmed-6716959
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher American Association for the Advancement of Science
record_format MEDLINE/PubMed
spelling pubmed-67169592019-09-06 Repair of tooth enamel by a biomimetic mineralization frontier ensuring epitaxial growth Shao, Changyu Jin, Biao Mu, Zhao Lu, Hao Zhao, Yueqi Wu, Zhifang Yan, Lumiao Zhang, Zhisen Zhou, Yanchun Pan, Haihua Liu, Zhaoming Tang, Ruikang Sci Adv Research Articles The regeneration of tooth enamel, the hardest biological tissue, remains a considerable challenge because its complicated and well-aligned apatite structure has not been duplicated artificially. We herein reveal that a rationally designed material composed of calcium phosphate ion clusters can be used to produce a precursor layer to induce the epitaxial crystal growth of enamel apatite, which mimics the biomineralization crystalline-amorphous frontier of hard tissue development in nature. After repair, the damaged enamel can be recovered completely because its hierarchical structure and mechanical properties are identical to those of natural enamel. The suggested phase transformation–based epitaxial growth follows a promising strategy for enamel regeneration and, more generally, for biomimetic reproduction of materials with complicated structure. American Association for the Advancement of Science 2019-08-30 /pmc/articles/PMC6716959/ /pubmed/31497647 http://dx.doi.org/10.1126/sciadv.aaw9569 Text en Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (http://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
spellingShingle Research Articles
Shao, Changyu
Jin, Biao
Mu, Zhao
Lu, Hao
Zhao, Yueqi
Wu, Zhifang
Yan, Lumiao
Zhang, Zhisen
Zhou, Yanchun
Pan, Haihua
Liu, Zhaoming
Tang, Ruikang
Repair of tooth enamel by a biomimetic mineralization frontier ensuring epitaxial growth
title Repair of tooth enamel by a biomimetic mineralization frontier ensuring epitaxial growth
title_full Repair of tooth enamel by a biomimetic mineralization frontier ensuring epitaxial growth
title_fullStr Repair of tooth enamel by a biomimetic mineralization frontier ensuring epitaxial growth
title_full_unstemmed Repair of tooth enamel by a biomimetic mineralization frontier ensuring epitaxial growth
title_short Repair of tooth enamel by a biomimetic mineralization frontier ensuring epitaxial growth
title_sort repair of tooth enamel by a biomimetic mineralization frontier ensuring epitaxial growth
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6716959/
https://www.ncbi.nlm.nih.gov/pubmed/31497647
http://dx.doi.org/10.1126/sciadv.aaw9569
work_keys_str_mv AT shaochangyu repairoftoothenamelbyabiomimeticmineralizationfrontierensuringepitaxialgrowth
AT jinbiao repairoftoothenamelbyabiomimeticmineralizationfrontierensuringepitaxialgrowth
AT muzhao repairoftoothenamelbyabiomimeticmineralizationfrontierensuringepitaxialgrowth
AT luhao repairoftoothenamelbyabiomimeticmineralizationfrontierensuringepitaxialgrowth
AT zhaoyueqi repairoftoothenamelbyabiomimeticmineralizationfrontierensuringepitaxialgrowth
AT wuzhifang repairoftoothenamelbyabiomimeticmineralizationfrontierensuringepitaxialgrowth
AT yanlumiao repairoftoothenamelbyabiomimeticmineralizationfrontierensuringepitaxialgrowth
AT zhangzhisen repairoftoothenamelbyabiomimeticmineralizationfrontierensuringepitaxialgrowth
AT zhouyanchun repairoftoothenamelbyabiomimeticmineralizationfrontierensuringepitaxialgrowth
AT panhaihua repairoftoothenamelbyabiomimeticmineralizationfrontierensuringepitaxialgrowth
AT liuzhaoming repairoftoothenamelbyabiomimeticmineralizationfrontierensuringepitaxialgrowth
AT tangruikang repairoftoothenamelbyabiomimeticmineralizationfrontierensuringepitaxialgrowth