Lack of multidrug resistance-associated protein 4 (Mrp4) alters the kinetics of acetaminophen toxicity

Acetaminophen (APAP) overdose is the most frequent cause of drug-induced liver injury in humans and a common chemical model to investigate genetic determinants of susceptibility to drug-induced liver injury (DILI). Previous studies performed in our laboratory identified the efflux transporter multid...

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Detalles Bibliográficos
Autores principales: Donepudi, Ajay C, Goedken, Michael J., Schuetz, John D., E Manautou, José
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717103/
https://www.ncbi.nlm.nih.gov/pubmed/31485416
http://dx.doi.org/10.1016/j.toxrep.2019.08.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717103/
https://www.ncbi.nlm.nih.gov/pubmed/31485416
http://dx.doi.org/10.1016/j.toxrep.2019.08.005

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