Cargando…

Lack of multidrug resistance-associated protein 4 (Mrp4) alters the kinetics of acetaminophen toxicity

Acetaminophen (APAP) overdose is the most frequent cause of drug-induced liver injury in humans and a common chemical model to investigate genetic determinants of susceptibility to drug-induced liver injury (DILI). Previous studies performed in our laboratory identified the efflux transporter multid...

Descripción completa

Detalles Bibliográficos
Autores principales:	Donepudi, Ajay C, Goedken, Michael J., Schuetz, John D., E Manautou, José
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717103/ https://www.ncbi.nlm.nih.gov/pubmed/31485416 http://dx.doi.org/10.1016/j.toxrep.2019.08.005

Ejemplares similares

The modulation of transcriptional expression and inhibition of multidrug resistance associated protein 4 (MRP4) by analgesics and their primary metabolites
por: Scialis, Renato J., et al.
Publicado: (2020)

Functional Expression of Multidrug Resistance Protein 4 MRP4/ABCC4
por: Hardy, David, et al.
Publicado: (2019)

Stabilization of Human Multidrug Resistance Protein 4 (MRP4/ABCC4) Using Novel Solubilization Agents
por: Hardy, David, et al.
Publicado: (2019)

Human multidrug resistance protein 4 (MRP4) is a cellular efflux transporter for paracetamol glutathione and cysteine conjugates
por: Koenderink, Jan B., et al.
Publicado: (2020)

Discovery of Novel Symmetrical 1,4-Dihydropyridines as Inhibitors of Multidrug-Resistant Protein (MRP4) Efflux Pump for Anticancer Therapy
por: Döring, Henry, et al.
Publicado: (2020)

Multidrug resistance-associated protein-1 (MRP1) genetic variants, MRP1 protein levels and severity of COPD
por: Budulac, Simona E, et al.
Publicado: (2010)

Expression levels of multidrug resistance-associated protein 4 (MRP4) in human leukemia and lymphoma cell lines, and the inhibitory effects of the MRP-specific inhibitor MK-571 on methotrexate distribution in rats
por: TAKEUCHI, KENJI, et al.
Publicado: (2012)

Expression of the multidrug resistance-associated protein (MRP) gene in colorectal carcinomas.
por: Fillpits, M., et al.
Publicado: (1997)

Multidrug transporter MRP4/ABCC4 as a key determinant of pancreatic cancer aggressiveness
por: Sahores, A., et al.
Publicado: (2020)

Structural basis for substrate and inhibitor recognition of human multidrug transporter MRP4
por: Huang, Ying, et al.
Publicado: (2023)

Altered MRP is associated with multidrug resistance and reduced drug accumulation in human SW-1573 cells.
por: Eijdems, E. W., et al.
Publicado: (1995)

Dual Role of cAMP in the Transcriptional Regulation of Multidrug Resistance-Associated Protein 4 (MRP4) in Pancreatic Adenocarcinoma Cell Lines
por: Carozzo, Alejandro, et al.
Publicado: (2015)

Expression and role of PGP, BCRP, MRP1 and MRP3 in multidrug resistance of canine mammary cancer cells
por: Pawłowski, Karol M, et al.
Publicado: (2013)

Characterization of SN38-resistant T47D breast cancer cell sublines overexpressing BCRP, MRP1, MRP2, MRP3, and MRP4
por: Lee, Hee-Jeong, et al.
Publicado: (2022)

Alterations in expression of the multidrug resistance-associated protein (MRP) gene in high-grade transitional cell carcinoma of the bladder.
por: Clifford, S. C., et al.
Publicado: (1996)

Reversal of MRP7 (ABCC10)-Mediated Multidrug Resistance by Tariquidar
por: Sun, Yue-Li, et al.
Publicado: (2013)

Overexpression of MRP4 (ABCC4) and MRP5 (ABCC5) confer resistance to the nucleoside analogs cytarabine and troxacitabine, but not gemcitabine
por: Adema, Auke D, et al.
Publicado: (2014)

Involvement of human and canine MRP1 and MRP4 in benzylpenicillin transport
por: Zhao, Xiaofen, et al.
Publicado: (2019)

Vinblastine and sulfinpyrazone export by the multidrug resistance protein MRP2 is associated with glutathione export
por: Evers, R, et al.
Publicado: (2000)

The prognostic significance of expression of the multidrug resistance-associated protein (MRP) in primary breast cancer.
por: Nooter, K., et al.
Publicado: (1997)

Clinicopathological Impact of ABCC1/MRP1 and ABCC4/MRP4 in Epithelial Ovarian Carcinoma
por: Bagnoli, Marina, et al.
Publicado: (2013)

Crocin suppresses multidrug resistance in MRP overexpressing ovarian cancer cell line
por: Mahdizadeh, Shadi, et al.
Publicado: (2016)

Expression of the multidrug resistance-associated protein (MRP) gene in non-small-cell lung cancer.
por: Ota, E., et al.
Publicado: (1995)

Epitope mapping of monoclonal antibodies specific for the 190-kDa multidrug resistance protein (MRP).
por: Hipfner, D. R., et al.
Publicado: (1998)

Tenofovir Renal Proximal Tubular Toxicity Is Regulated By OAT1 and MRP4 Transporters
por: Kohler, James J., et al.
Publicado: (2011)

Expression of Drug Pump Protein MRP2 in Lipopolysaccharide-Treated Rats and its Impact on the Disposition of Acetaminophen
por: Hassany, Mitra, et al.
Publicado: (2011)

Disruption of a Plasmodium falciparum Multidrug Resistance-associated Protein (PfMRP) Alters Its Fitness and Transport of Antimalarial Drugs and Glutathione
por: Raj, Dipak Kumar, et al.
Publicado: (2009)

Expression of multidrug resistance-associated protein (MRP), MDR1 and DNA topoisomerase II in human multidrug-resistant bladder cancer cell lines.
por: Hasegawa, S., et al.
Publicado: (1995)

Discovery of novel multidrug resistance protein 4 (MRP4) inhibitors as active agents reducing resistance to anticancer drug 6-Mercaptopurine (6-MP) by structure and ligand-based virtual screening
por: Chen, Ya, et al.
Publicado: (2018)

Kinetic Interpretation of the Importance of OATP1B3 and MRP2 in Docetaxel-Induced Hematopoietic Toxicity
por: Yamada, A, et al.
Publicado: (2014)

Chemosensitisation of spontaneous multidrug resistance by a 1,4-dihydropyridine analogue and verapamil in human glioma cell lines overexpressing MRP or MDR1.
por: Abe, T., et al.
Publicado: (1995)

Multidrug Resistance-Associated Protein 1 (MRP1) mediated vincristine resistance: effects of N-acetylcysteine and Buthionine Sulfoximine
por: Akan, Ilhan, et al.
Publicado: (2005)

Prognostic Significance of Multidrug Resistance Gene 1 (MDR1), Multidrug Resistance-related Protein (MRP) and Lung Resistance Protein (LRP) mRNA Expression in Acute Leukemia
por: Huh, Hee Jin, et al.
Publicado: (2006)

Role of multidrug resistance protein 2 (MRP2) in chemoresistance and clinical outcome in oesophageal squamous cell carcinoma
por: Yamasaki, M, et al.
Publicado: (2011)

Multidrug Resistance-Associated Protein 2 (MRP2) Mediated Transport of Oxaliplatin-Derived Platinum in Membrane Vesicles
por: Myint, Khine, et al.
Publicado: (2015)

Synthesis and biological evaluation of novel quinoline analogs of ketoprofen as multidrug resistance protein 2 (MRP2) inhibitors
por: Mosaffa, Fatemeh, et al.
Publicado: (2021)

Multidrug Resistance Protein-4 Influences Aspirin Toxicity in Human Cell Line
por: Massimi, Isabella, et al.
Publicado: (2015)

Correction: Döring et al. Discovery of Novel Symmetrical 1,4-Dihydropyridines as Inhibitors of Multidrug-Resistant Protein (MRP4) Efflux Pump for Anticancer Therapy. Molecules 2021, 26, 18
por: Döring, Henry, et al.
Publicado: (2022)

Reversing Multidrug Resistance in Caco-2 by Silencing MDR1, MRP1, MRP2, and BCL-2/BCL-xL Using Liposomal Antisense Oligonucleotides
por: Lo, Yu-Li, et al.
Publicado: (2014)

Targeting Nucleotide Binding Domain of Multidrug Resistance-associated Protein-1 (MRP1) for the Reversal of Multi Drug Resistance in Cancer
por: Dhasmana, Divya, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_9tcgsdafllvqccivujg2378e70