Molecular docking and QSAR studies for modeling the antimalarial activity of hybrids 4-anilinoquinoline-triazines derivatives with the wild-type and mutant receptor pf-DHFR

Plasmodium falciparum dihydrofolate reductase (pf-DHFR) is one of the several targets in the treatment of malaria. Double and quadruple mutations at residues 51, 59, 108, and 164 of pf-DHFR have been linked to antifolate resistance. Several efforts are underway to overcome this drug resistance and t...

Descripción completa

Detalles Bibliográficos
Autores principales: Hadni, Hanine, Elhallaoui, Menana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717158/
https://www.ncbi.nlm.nih.gov/pubmed/31485537
http://dx.doi.org/10.1016/j.heliyon.2019.e02357

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717158/
https://www.ncbi.nlm.nih.gov/pubmed/31485537
http://dx.doi.org/10.1016/j.heliyon.2019.e02357

Ejemplares similares