In-depth immunophenotyping data relating to IL-17Ab modulation of circulating Treg/Th17 cells and of in situ infiltrated inflammatory monocytes in the onset of gouty inflammation

The data supplied in this work are related to the research article entitled “IL-17A neutralizing antibody regulates monosodium urate crystal-induced gouty inflammation” [1]. This data article presents the results of the gating strategy applied to identify Treg population in peripheral blood of mice...

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Detalles Bibliográficos
Autores principales: Raucci, Federica, Iqbal, Asif J., Saviano, Anella, Casillo, Gian Marco, Russo, Marina, Lezama, Danielle, Mascolo, Nicola, Maione, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Pharmacology, Toxicology and Pharmaceutical Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717213/
https://www.ncbi.nlm.nih.gov/pubmed/31489355
http://dx.doi.org/10.1016/j.dib.2019.104381
Descripción
Sumario:The data supplied in this work are related to the research article entitled “IL-17A neutralizing antibody regulates monosodium urate crystal-induced gouty inflammation” [1]. This data article presents the results of the gating strategy applied to identify Treg population in peripheral blood of mice injected with MSU crystals and MSU crystals + interleukin-17 antibody (IL-17Ab). Lastly, this article provides in-depth immunophenotyping data relating to all specific and isotype control antibodies used in the phenotypical characterization of circulating Treg (defined as CD4(+)CD25(+)Foxp3(+)), Th17 (defined as CD4(+)IL-17(+)) cells and joint-infiltrated (in situ) inflammatory monocytes (defined as B220(−)GR1(high)F480(high)CD115(+)).

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