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Associations between the phenotype and genotype of MnSOD and catalase in periodontal disease

BACKGROUND: Periodontal disease is an inflammatory disease in which pathogenic infections trigger a series of inflammatory responses and redox regulation. The hypothesis of this study was that a host’s redox regulation, as modified by genetic polymorphisms, may affect periodontal disease activities...

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Autores principales: Lee, Chang-Yu, Chang, Chia-Huang, Teng, Nai-Chia, Chang, Hung-Ming, Huang, Wan-Ting, Huang, Yung-Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717336/
https://www.ncbi.nlm.nih.gov/pubmed/31470840
http://dx.doi.org/10.1186/s12903-019-0877-3
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author Lee, Chang-Yu
Chang, Chia-Huang
Teng, Nai-Chia
Chang, Hung-Ming
Huang, Wan-Ting
Huang, Yung-Kai
author_facet Lee, Chang-Yu
Chang, Chia-Huang
Teng, Nai-Chia
Chang, Hung-Ming
Huang, Wan-Ting
Huang, Yung-Kai
author_sort Lee, Chang-Yu
collection PubMed
description BACKGROUND: Periodontal disease is an inflammatory disease in which pathogenic infections trigger a series of inflammatory responses and redox regulation. The hypothesis of this study was that a host’s redox regulation, as modified by genetic polymorphisms, may affect periodontal disease activities (including the plaque index (PlI), bleeding on probing (BOP), and pocket depth (PD)) during periodontal therapy. METHODS: In total, 175 patients diagnosed with periodontitis were recruited from the Department of Periodontology, Taipei Medical University Hospital. Both saliva samples and clinical measurements (PlI, BOP, and PD) were taken at the baseline and at 1 month after completing treatment. Salivary manganese superoxide dismutase (MnSOD) and catalase, and corresponding genetic polymorphisms (MnSOD, T47C, rs4880 and Catalase, C-262 T, rs1001179) were determined. The extent of change (Δ) of MnSOD or catalase was calculated by subtracting the concentration after completing treatment from that at the baseline. RESULTS: Subjects who carried the Catalase CC genotype had significantly higher salivary MnSOD or catalase levels. The MnSOD genotype had a significant effect on the percentage of PDs of 4~9 mm (p = 0.02), and salivary ΔMnSOD had a significant effect on the PlI (p = 0.03). The Catalase genotype had a significant effect on the PlI (p = 0.01~0.04), but the effect was not found for the mean PlI or PD. There was a significant interaction between the MnSOD genotype and salivary ΔMnSOD on PDs of 4~9 mm. After adjusting for gender, years of schooling, smoking status, and alcohol consumption, subjects with ΔMnSOD of < 0 μg/ml or Δcatalase of < 0 μg/ml had significantly higher 5.58- or 5.17-fold responses to scaling and root planing treatment. CONCLUSIONS: The MnSOD T47C genotype interferes with the phenotype of salivary antioxidant level, alters MnSOD levels, and influences the PD recovery. MnSOD and catalase gene polymorphism associated with phenotype expression and susceptibility in periodontal root planing treatment responses. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12903-019-0877-3) contains supplementary material, which is available to authorized users.
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spelling pubmed-67173362019-09-06 Associations between the phenotype and genotype of MnSOD and catalase in periodontal disease Lee, Chang-Yu Chang, Chia-Huang Teng, Nai-Chia Chang, Hung-Ming Huang, Wan-Ting Huang, Yung-Kai BMC Oral Health Research Article BACKGROUND: Periodontal disease is an inflammatory disease in which pathogenic infections trigger a series of inflammatory responses and redox regulation. The hypothesis of this study was that a host’s redox regulation, as modified by genetic polymorphisms, may affect periodontal disease activities (including the plaque index (PlI), bleeding on probing (BOP), and pocket depth (PD)) during periodontal therapy. METHODS: In total, 175 patients diagnosed with periodontitis were recruited from the Department of Periodontology, Taipei Medical University Hospital. Both saliva samples and clinical measurements (PlI, BOP, and PD) were taken at the baseline and at 1 month after completing treatment. Salivary manganese superoxide dismutase (MnSOD) and catalase, and corresponding genetic polymorphisms (MnSOD, T47C, rs4880 and Catalase, C-262 T, rs1001179) were determined. The extent of change (Δ) of MnSOD or catalase was calculated by subtracting the concentration after completing treatment from that at the baseline. RESULTS: Subjects who carried the Catalase CC genotype had significantly higher salivary MnSOD or catalase levels. The MnSOD genotype had a significant effect on the percentage of PDs of 4~9 mm (p = 0.02), and salivary ΔMnSOD had a significant effect on the PlI (p = 0.03). The Catalase genotype had a significant effect on the PlI (p = 0.01~0.04), but the effect was not found for the mean PlI or PD. There was a significant interaction between the MnSOD genotype and salivary ΔMnSOD on PDs of 4~9 mm. After adjusting for gender, years of schooling, smoking status, and alcohol consumption, subjects with ΔMnSOD of < 0 μg/ml or Δcatalase of < 0 μg/ml had significantly higher 5.58- or 5.17-fold responses to scaling and root planing treatment. CONCLUSIONS: The MnSOD T47C genotype interferes with the phenotype of salivary antioxidant level, alters MnSOD levels, and influences the PD recovery. MnSOD and catalase gene polymorphism associated with phenotype expression and susceptibility in periodontal root planing treatment responses. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12903-019-0877-3) contains supplementary material, which is available to authorized users. BioMed Central 2019-08-30 /pmc/articles/PMC6717336/ /pubmed/31470840 http://dx.doi.org/10.1186/s12903-019-0877-3 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Lee, Chang-Yu
Chang, Chia-Huang
Teng, Nai-Chia
Chang, Hung-Ming
Huang, Wan-Ting
Huang, Yung-Kai
Associations between the phenotype and genotype of MnSOD and catalase in periodontal disease
title Associations between the phenotype and genotype of MnSOD and catalase in periodontal disease
title_full Associations between the phenotype and genotype of MnSOD and catalase in periodontal disease
title_fullStr Associations between the phenotype and genotype of MnSOD and catalase in periodontal disease
title_full_unstemmed Associations between the phenotype and genotype of MnSOD and catalase in periodontal disease
title_short Associations between the phenotype and genotype of MnSOD and catalase in periodontal disease
title_sort associations between the phenotype and genotype of mnsod and catalase in periodontal disease
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717336/
https://www.ncbi.nlm.nih.gov/pubmed/31470840
http://dx.doi.org/10.1186/s12903-019-0877-3
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