Cargando…

Novel analytical methods to interpret large sequencing data from small sample sizes

BACKGROUND: Targeted therapies have greatly improved cancer patient prognosis. For instance, chronic myeloid leukemia is now well treated with imatinib, a tyrosine kinase inhibitor. Around 80% of the patients reach complete remission. However, despite its great efficiency, some patients are resistan...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lichou, Florence, Orazio, Sébastien, Dulucq, Stéphanie, Etienne, Gabriel, Longy, Michel, Hubert, Christophe, Groppi, Alexis, Monnereau, Alain, Mahon, François-Xavier, Turcq, Béatrice
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Primary Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717342/ https://www.ncbi.nlm.nih.gov/pubmed/31470908 http://dx.doi.org/10.1186/s40246-019-0235-1

Ejemplares similares

A genome‐scale CRISPR knock‐out screen in chronic myeloid leukemia identifies novel drug resistance mechanisms along with intrinsic apoptosis and MAPK signaling
por: Lewis, Matthieu, et al.
Publicado: (2020)

Second‐ or third‐generation tyrosine kinase inhibitors in first‐line treatment of chronic myeloid leukemia in general population: Is there a real benefit?
por: Canet, Jim, et al.
Publicado: (2021)

Dasatinib-Loaded Erythrocytes Trigger Apoptosis in Untreated Chronic Myelogenous Leukemic Cells: A Cellular Reservoir Participating in Dasatinib Efficiency
por: Airiau, Kelly, et al.
Publicado: (2018)

Ovarian cyst removal influences ovarian reserve dependent on histology, size and type of operation
por: Henes, Melanie, et al.
Publicado: (2018)

The relationship between breast size and aspects of health and psychological wellbeing in mature-aged women
por: Spencer, Linda, et al.
Publicado: (2020)

Killer immunoglobulin‐like receptor genotypes and chronic myeloid leukemia outcomes after imatinib cessation for treatment‐free remission
por: Dumas, Pierre‐Yves, et al.
Publicado: (2019)

Functional studies of GWAS variants are gaining momentum
por: Lichou, Florence, et al.
Publicado: (2020)

Factors related to the relative survival of patients with diffuse large B-cell lymphoma in a population-based study in France: does socio-economic status have a role?
por: Le Guyader-Peyrou, Sandra, et al.
Publicado: (2017)

α-Defensin 1-3 And α-Defensin 4 as Predictive Markers of Imatinib Resistance and Relapse in CML Patients
por: Etienne, Gabriel, et al.
Publicado: (2011)

Optimal search strategies for identifying mental health content in MEDLINE: an analytic survey
por: Wilczynski, Nancy L, et al.
Publicado: (2006)

A Single Nucleotide Polymorphism in cBIM Is Associated with a Slower Achievement of Major Molecular Response in Chronic Myeloid Leukaemia Treated with Imatinib
por: Augis, Vanessa, et al.
Publicado: (2013)

Incidence and outcome of BCR‐ABL mutated chronic myeloid leukemia patients who failed to tyrosine kinase inhibitors
por: Etienne, Gabriel, et al.
Publicado: (2019)

Driving mosaicism: somatic variants in reference population databases and effect on variant interpretation in rare genetic disease
por: Avramović, Vladimir, et al.
Publicado: (2021)

Femoral vein size in newborns and infants: preliminary investigation
por: Akingbola, Olugbenga A, et al.
Publicado: (2000)

P938: SURVIVAL OF PATIENTS WITH MULTIPLE MYELOMA IN THE GENERAL POPULATION BASED ON DATA FROM TWO FRENCH CANCER REGISTRIES
por: Hulin, Cyrille, et al.
Publicado: (2023)

The impact of sample size and marker selection on the study of haplotype structures
por: Sun, Xiao, et al.
Publicado: (2004)

BRCA1 and BRCA2 mutations and clinical interpretation in 398 ovarian cancer patients: comparison with breast cancer variants in a similar population
por: Cardoso, Florencia C., et al.
Publicado: (2018)

Incidences of Deep Molecular Responses and Treatment-Free Remission in de Novo CP-CML Patients
por: Etienne, Gabriel, et al.
Publicado: (2020)

Deep molecular responses for treatment‐free remission in chronic myeloid leukemia
por: Dulucq, Stéphanie, et al.
Publicado: (2016)

Relevance of treatment‐free remission recommendations in chronic phase chronic leukemia patients treated with frontline tyrosine kinase inhibitors
por: Etienne, Gabriel, et al.
Publicado: (2021)

A new, fast and semi-automated size determination method (SASDM) for studying multicellular tumor spheroids
por: Monazzam, Azita, et al.
Publicado: (2005)

Evidence that DNA repair genes, a family of tumor suppressor genes, are associated with evolution rate and size of genomes
por: Voskarides, Konstantinos, et al.
Publicado: (2019)

Experimental evidence of gradual size‐dependent shifts in body size and growth of fish in response to warming
por: Huss, Magnus, et al.
Publicado: (2019)

Targeted tumor therapy by Rubia tinctorum L.: analytical characterization of hydroxyanthraquinones and investigation of their selective cytotoxic, adhesion and migration modulator effects on melanoma cell lines (A2058 and HT168-M1)
por: Lajkó, Eszter, et al.
Publicado: (2015)

Shifting parental roles, caregiving practices and the face of child development in low resource informal settlements of Nairobi: experiences of community health workers and school teachers
por: Kumar, Manasi, et al.
Publicado: (2018)

Woody vegetation dynamics in the tropical and subtropical Andes from 2001 to 2014: Satellite image interpretation and expert validation
por: Aide, T. Mitchell, et al.
Publicado: (2019)

Alcohol significantly lowers the seizure threshold in mice when co-administered with bupropion hydrochloride
por: Silverstone, Peter H, et al.
Publicado: (2008)

Convulsive liability of bupropion hydrochloride metabolites in Swiss albino mice
por: Silverstone, Peter H, et al.
Publicado: (2008)

Effect of increasing intraperitoneal infusion rates on bupropion hydrochloride-induced seizures in mice
por: Silverstone, Peter H, et al.
Publicado: (2008)

Estimating the global distribution of field size using crowdsourcing
por: Lesiv, Myroslava, et al.
Publicado: (2018)

A clinical comparison of schizophrenia with and without pre-onset cannabis use disorder: a retrospective cohort study using categorical and dimensional approaches
por: Sarrazin, Samuel, et al.
Publicado: (2015)

Altered expression of estrogen receptor-α variant messenger RNAs between adjacent normal breast and breast tumor tissues
por: Leygue, Etienne, et al.
Publicado: (2000)

Circulating tumor microemboli (CTM) and vimentin+ circulating tumor cells (CTCs) detected by a size-based platform predict worse prognosis in advanced colorectal cancer patients during chemotherapy
por: Zhang, Dejun, et al.
Publicado: (2017)

Characterization of analytical errors in thromboelastography interpretation
por: Mukhopadhyay, Tapasyapreeti, et al.
Publicado: (2020)

The implications of women’s activity limitations and role disruptions during breast cancer survivorship
por: Keesing, Sharon, et al.
Publicado: (2018)

Telehealth intervention for Latina breast cancer survivors: A pilot
por: Meneses, Karen, et al.
Publicado: (2018)

Trajectories of lower back, upper back, and pelvic girdle pain during pregnancy and early postpartum in primiparous women
por: Dunn, Guinn, et al.
Publicado: (2019)

Reproductive health care utilization among refugees in Jordan: Provisional support and domestic violence
por: Pierce, Hayley
Publicado: (2019)

Hysterectomy for benign conditions: Complications relative to surgical approach and other variables that lead to post-operative readmission within 90 days of surgery
por: Lonky, Neal M, et al.
Publicado: (2017)

The relationship between employment status and depression symptomatology among women at risk for postpartum depression
por: Lewis, Beth A, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_cl8dsp0357gmof6f1jdgpe84sv