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Primary cardiac dedifferentiated liposarcoma in a middle-aged female: a case report
BACKGROUND: Primary malignant cardiac tumors are extremely rare and can present with the same nonspecific characteristics as benign primary cardiac tumors. We herein describe a middle-aged female with an intracavitary, irregular atrial mass who experienced partial surgical resection. The atrial mass...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717363/ https://www.ncbi.nlm.nih.gov/pubmed/31470882 http://dx.doi.org/10.1186/s13019-019-0973-0 |
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author | Shen, Jiayu Fang, Zhi Zhang, Yahan Guo, Yingqiang |
author_facet | Shen, Jiayu Fang, Zhi Zhang, Yahan Guo, Yingqiang |
author_sort | Shen, Jiayu |
collection | PubMed |
description | BACKGROUND: Primary malignant cardiac tumors are extremely rare and can present with the same nonspecific characteristics as benign primary cardiac tumors. We herein describe a middle-aged female with an intracavitary, irregular atrial mass who experienced partial surgical resection. The atrial mass which was recognized as myxoma before surgery was finally diagnosed as dedifferentiated liposarcoma (DDLPS) by postoperative pathological examination. CASE PRESENTATION: The patient, a 61-year-old female, presented to the emergency room because of progressive chest congestion and shortage of liberties for 6 months and orthopnoea and paroxysmal nocturnal dyspnea for 3 days. The laboratory examinations confirmed no abnormalities. The thoracic computed tomography (CT) scan showed massive hydropericardium, pleural effusion and left atrium occupying lesion. The transesophageal echocardiography (TEE) confirmed an intracavitary and irregular left atrial mass, limiting the mitral valve inflow and pulmonary venous blood reflux. The positron emission tomography/computed tomography (PET/CT) revealed high grade fluorodeoxyglucose uptake only in the intracavitary mass which near the mitral valve. According to operative exploration, the intracavitary mass had invaded the mitral annulus and posterior wall of left ventricle which cannot be resected completely, we did merely partial surgical resection to relieve the patient’s symptoms. Postoperative immunohistochemical stain confirmed the diagnosis of DDLPS. The patient was transferred to the oncology department for further therapy. Unfortunately, the patient was detected with brain metastasis 1 month later and died within 5 months after the surgery. CONCLUSIONS: Primary cardiac DDLPS is an extremely rare histological subtype of undifferentiated pleomorphic sarcomas which present the same nonspecific characteristics as benign primary cardiac tumors. Even though surgical resection combined with chemotherapy or radiotherapy remains the mainstream treatment strategy, the prognosis of cardiac malignancy is poor with high mortality. Novel management strategies need to be further explored. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13019-019-0973-0) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-6717363 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-67173632019-09-06 Primary cardiac dedifferentiated liposarcoma in a middle-aged female: a case report Shen, Jiayu Fang, Zhi Zhang, Yahan Guo, Yingqiang J Cardiothorac Surg Case Report BACKGROUND: Primary malignant cardiac tumors are extremely rare and can present with the same nonspecific characteristics as benign primary cardiac tumors. We herein describe a middle-aged female with an intracavitary, irregular atrial mass who experienced partial surgical resection. The atrial mass which was recognized as myxoma before surgery was finally diagnosed as dedifferentiated liposarcoma (DDLPS) by postoperative pathological examination. CASE PRESENTATION: The patient, a 61-year-old female, presented to the emergency room because of progressive chest congestion and shortage of liberties for 6 months and orthopnoea and paroxysmal nocturnal dyspnea for 3 days. The laboratory examinations confirmed no abnormalities. The thoracic computed tomography (CT) scan showed massive hydropericardium, pleural effusion and left atrium occupying lesion. The transesophageal echocardiography (TEE) confirmed an intracavitary and irregular left atrial mass, limiting the mitral valve inflow and pulmonary venous blood reflux. The positron emission tomography/computed tomography (PET/CT) revealed high grade fluorodeoxyglucose uptake only in the intracavitary mass which near the mitral valve. According to operative exploration, the intracavitary mass had invaded the mitral annulus and posterior wall of left ventricle which cannot be resected completely, we did merely partial surgical resection to relieve the patient’s symptoms. Postoperative immunohistochemical stain confirmed the diagnosis of DDLPS. The patient was transferred to the oncology department for further therapy. Unfortunately, the patient was detected with brain metastasis 1 month later and died within 5 months after the surgery. CONCLUSIONS: Primary cardiac DDLPS is an extremely rare histological subtype of undifferentiated pleomorphic sarcomas which present the same nonspecific characteristics as benign primary cardiac tumors. Even though surgical resection combined with chemotherapy or radiotherapy remains the mainstream treatment strategy, the prognosis of cardiac malignancy is poor with high mortality. Novel management strategies need to be further explored. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13019-019-0973-0) contains supplementary material, which is available to authorized users. BioMed Central 2019-08-30 /pmc/articles/PMC6717363/ /pubmed/31470882 http://dx.doi.org/10.1186/s13019-019-0973-0 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Case Report Shen, Jiayu Fang, Zhi Zhang, Yahan Guo, Yingqiang Primary cardiac dedifferentiated liposarcoma in a middle-aged female: a case report |
title | Primary cardiac dedifferentiated liposarcoma in a middle-aged female: a case report |
title_full | Primary cardiac dedifferentiated liposarcoma in a middle-aged female: a case report |
title_fullStr | Primary cardiac dedifferentiated liposarcoma in a middle-aged female: a case report |
title_full_unstemmed | Primary cardiac dedifferentiated liposarcoma in a middle-aged female: a case report |
title_short | Primary cardiac dedifferentiated liposarcoma in a middle-aged female: a case report |
title_sort | primary cardiac dedifferentiated liposarcoma in a middle-aged female: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717363/ https://www.ncbi.nlm.nih.gov/pubmed/31470882 http://dx.doi.org/10.1186/s13019-019-0973-0 |
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