Aspulvinone O, a natural inhibitor of GOT1 suppresses pancreatic ductal adenocarcinoma cells growth by interfering glutamine metabolism

BACKGROUND: Distinctive from their normal counterparts, cancer cells exhibit unique metabolic dependencies on glutamine to fuel anabolic processes. Specifically, pancreatic ductal adenocarcinoma (PDAC) cells rely on an unconventional metabolic pathway catalyzed by aspartate transaminase 1 (GOT1) to...

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Detalles Bibliográficos
Autores principales: Sun, Weiguang, Luan, Shanshan, Qi, Changxing, Tong, Qingyi, Yan, Shan, Li, Hua, Zhang, Yonghui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717386/
https://www.ncbi.nlm.nih.gov/pubmed/31470862
http://dx.doi.org/10.1186/s12964-019-0425-4

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