Tspan18 is a novel regulator of the Ca(2+) channel Orai1 and von Willebrand factor release in endothelial cells

Ca(2+) entry via Orai1 store-operated Ca(2+) channels in the plasma membrane is critical to cell function, and Orai1 loss causes severe immunodeficiency and developmental defects. The tetraspanins are a superfamily of transmembrane proteins that interact with specific ‘partner proteins’ and regulate...

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Detalles Bibliográficos
Autores principales: Noy, Peter J., Gavin, Rebecca L., Colombo, Dario, Haining, Elizabeth J., Reyat, Jasmeet S., Payne, Holly, Thielmann, Ina, Lokman, Adam B., Neag, Georgiana, Yang, Jing, Lloyd, Tammy, Harrison, Neale, Heath, Victoria L., Gardiner, Chris, Whitworth, Katharine M., Robinson, Joseph, Koo, Chek Z., Di Maio, Alessandro, Harrison, Paul, Lee, Steven P., Michelangeli, Francesco, Kalia, Neena, Rainger, G. Ed, Nieswandt, Bernhard, Brill, Alexander, Watson, Steve P., Tomlinson, Michael G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ferrata Storti Foundation 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717597/
https://www.ncbi.nlm.nih.gov/pubmed/30573509
http://dx.doi.org/10.3324/haematol.2018.194241

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