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The comparison of the impact of arterial stiffness and central pressure on left ventricular geometry and diastolic function

BACKGROUND: This study was performed to compare the associations of brachial-ankle pulse wave velocity (baPWV) and central blood pressure (CBP) measurements with left ventricular (LV) geometry and diastolic function. METHODS: A total of 77 subjects (64.5 ± 10.8 years, 67.5% females) without document...

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Autores principales: Kim, Hack-Lyoung, Lim, Woo-Hyun, Seo, Jae-Bin, Kim, Sang-Hyun, Zo, Zoo-Hee, Kim, Myung-A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717628/
https://www.ncbi.nlm.nih.gov/pubmed/31497312
http://dx.doi.org/10.1186/s40885-019-0125-9
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author Kim, Hack-Lyoung
Lim, Woo-Hyun
Seo, Jae-Bin
Kim, Sang-Hyun
Zo, Zoo-Hee
Kim, Myung-A
author_facet Kim, Hack-Lyoung
Lim, Woo-Hyun
Seo, Jae-Bin
Kim, Sang-Hyun
Zo, Zoo-Hee
Kim, Myung-A
author_sort Kim, Hack-Lyoung
collection PubMed
description BACKGROUND: This study was performed to compare the associations of brachial-ankle pulse wave velocity (baPWV) and central blood pressure (CBP) measurements with left ventricular (LV) geometry and diastolic function. METHODS: A total of 77 subjects (64.5 ± 10.8 years, 67.5% females) without documented cardiovascular disease were prospectively recruited. All subjects underwent transthoracic echocardiography, baPWV and noninvasive measurement of CBP on the same day. RESULTS: In simple linear correlation analyses, neither baPWV nor CBP was associated with LV mass index or relative wall thickness (P > 0.05 for each). Although baPWV significantly correlated with septal e´ velocity in simple linear correlation analyses (r = 0.258, P = 0.025), the significance was lost after controlling for potential confounder (P = 0.881). In simple linear correlation analyses, central systolic blood pressure (CSBP) and central pulse pressure (CPP) significantly correlated with both septal e´ velocity or E/e´ (P <  0.05 for each); however, neither central diastolic nor mean arterial pressures was associated with both septal e´ velocity and E/e´ (P > 0.05 for each). After controlling for confounders, including age, sex and body mass index, CSBP correlated with septal e´ velocity (β = − 0.258, P = 0.025), but not with E/e´ (P = 0.074). CPP correlated with both septal e´ velocity (β = − 0.300, P = 0.014) and E/e´ (β = 0.428, P = 0.002) in the same multivariable model. CONCLUSIONS: In subjects without documented cardiovascular disease, CSBP and CPP may be more strongly associated with LV diastolic function than baPWV. Further studies with a larger sample size are needed to confirm our results.
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spelling pubmed-67176282019-09-06 The comparison of the impact of arterial stiffness and central pressure on left ventricular geometry and diastolic function Kim, Hack-Lyoung Lim, Woo-Hyun Seo, Jae-Bin Kim, Sang-Hyun Zo, Zoo-Hee Kim, Myung-A Clin Hypertens Research BACKGROUND: This study was performed to compare the associations of brachial-ankle pulse wave velocity (baPWV) and central blood pressure (CBP) measurements with left ventricular (LV) geometry and diastolic function. METHODS: A total of 77 subjects (64.5 ± 10.8 years, 67.5% females) without documented cardiovascular disease were prospectively recruited. All subjects underwent transthoracic echocardiography, baPWV and noninvasive measurement of CBP on the same day. RESULTS: In simple linear correlation analyses, neither baPWV nor CBP was associated with LV mass index or relative wall thickness (P > 0.05 for each). Although baPWV significantly correlated with septal e´ velocity in simple linear correlation analyses (r = 0.258, P = 0.025), the significance was lost after controlling for potential confounder (P = 0.881). In simple linear correlation analyses, central systolic blood pressure (CSBP) and central pulse pressure (CPP) significantly correlated with both septal e´ velocity or E/e´ (P <  0.05 for each); however, neither central diastolic nor mean arterial pressures was associated with both septal e´ velocity and E/e´ (P > 0.05 for each). After controlling for confounders, including age, sex and body mass index, CSBP correlated with septal e´ velocity (β = − 0.258, P = 0.025), but not with E/e´ (P = 0.074). CPP correlated with both septal e´ velocity (β = − 0.300, P = 0.014) and E/e´ (β = 0.428, P = 0.002) in the same multivariable model. CONCLUSIONS: In subjects without documented cardiovascular disease, CSBP and CPP may be more strongly associated with LV diastolic function than baPWV. Further studies with a larger sample size are needed to confirm our results. BioMed Central 2019-09-01 /pmc/articles/PMC6717628/ /pubmed/31497312 http://dx.doi.org/10.1186/s40885-019-0125-9 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Kim, Hack-Lyoung
Lim, Woo-Hyun
Seo, Jae-Bin
Kim, Sang-Hyun
Zo, Zoo-Hee
Kim, Myung-A
The comparison of the impact of arterial stiffness and central pressure on left ventricular geometry and diastolic function
title The comparison of the impact of arterial stiffness and central pressure on left ventricular geometry and diastolic function
title_full The comparison of the impact of arterial stiffness and central pressure on left ventricular geometry and diastolic function
title_fullStr The comparison of the impact of arterial stiffness and central pressure on left ventricular geometry and diastolic function
title_full_unstemmed The comparison of the impact of arterial stiffness and central pressure on left ventricular geometry and diastolic function
title_short The comparison of the impact of arterial stiffness and central pressure on left ventricular geometry and diastolic function
title_sort comparison of the impact of arterial stiffness and central pressure on left ventricular geometry and diastolic function
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717628/
https://www.ncbi.nlm.nih.gov/pubmed/31497312
http://dx.doi.org/10.1186/s40885-019-0125-9
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