Reversal effect of FW-04-806, a macrolide dilactone compound, on multidrug resistance mediated by ABCB1 and ABCG2 in vitro and in vivo

BACKGROUND: Overexpression of ATP-binding cassette (ABC) transporters, such as ABCB1 and ABCG2, has been proved to be a major trigger for multidrug resistance (MDR) in certain types of cancer. A promising approach to reverse MDR is the combined use of nontoxic and potent ABC transporters inhibitor w...

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Detalles Bibliográficos
Autores principales: Zhang, Zhiqiang, Ma, Chunling, Li, Peng, Wu, Min, Ye, Shengnan, Fu, Liwu, Xu, Jianhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717650/
https://www.ncbi.nlm.nih.gov/pubmed/31472682
http://dx.doi.org/10.1186/s12964-019-0408-5

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