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Relationship between natural killer cell activity and glucose control in patients with type 2 diabetes and prediabetes
AIMS/INTRODUCTION: Natural killer (NK) cells are cytotoxic lymphocytes critical to human immunity. Previous studies showed correlations between NK cell function and blood glucose concentrations. The purpose of the present study was to assess the NK cell activity and various metabolic parameters in p...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717814/ https://www.ncbi.nlm.nih.gov/pubmed/30618112 http://dx.doi.org/10.1111/jdi.13002 |
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author | Kim, Jung Hye Park, Kahui Lee, Sang Bae Kang, Shinae Park, Jong Suk Ahn, Chul Woo Nam, Ji Sun |
author_facet | Kim, Jung Hye Park, Kahui Lee, Sang Bae Kang, Shinae Park, Jong Suk Ahn, Chul Woo Nam, Ji Sun |
author_sort | Kim, Jung Hye |
collection | PubMed |
description | AIMS/INTRODUCTION: Natural killer (NK) cells are cytotoxic lymphocytes critical to human immunity. Previous studies showed correlations between NK cell function and blood glucose concentrations. The purpose of the present study was to assess the NK cell activity and various metabolic parameters in people with type 2 diabetes, prediabetes and normal glucose tolerance. MATERIALS AND METHODS: A total of 49 participants were enrolled in the study. Anthropometric and biochemical parameters including age, sex, body mass index, smoking status, blood pressure, fasting plasma glucose, C‐peptide, insulin, glycated hemoglobin, total cholesterol, triglyceride, high‐density lipoprotein cholesterol and low‐density lipoprotein cholesterol were assessed. The 75 g oral glucose tolerance test was carried out for 2‐h postload glucose level. Homeostatic model assessment was calculated for insulin resistance and β‐cell function. NK cell activity was measured by detecting the circulating interferon‐gamma level secreted from NK cells. RESULTS: NK cell activity was lower in patients with type 2 diabetes (768.01 ± 650.35) compared with those with prediabetes (2,396.08 ± 653.76, P < 0.001) and normal glucose tolerance (2,435.31 ± 633.22, P < 0.001). In patients with type 2 diabetes, there was a significant inverse linear relationship between NK cell activity and fasting plasma glucose, glycated hemoglobin, and 2‐h postload glucose level (all P < 0.001). Multiple regression analysis showed glycated hemoglobin to be an independent predictor of NK cell activity in patients with type 2 diabetes. CONCLUSIONS: Compared with individuals with normal glucose tolerance or prediabetes, type 2 diabetes patients have a reduced NK cell activity, and it is significantly related to glucose control. |
format | Online Article Text |
id | pubmed-6717814 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-67178142019-09-06 Relationship between natural killer cell activity and glucose control in patients with type 2 diabetes and prediabetes Kim, Jung Hye Park, Kahui Lee, Sang Bae Kang, Shinae Park, Jong Suk Ahn, Chul Woo Nam, Ji Sun J Diabetes Investig Articles AIMS/INTRODUCTION: Natural killer (NK) cells are cytotoxic lymphocytes critical to human immunity. Previous studies showed correlations between NK cell function and blood glucose concentrations. The purpose of the present study was to assess the NK cell activity and various metabolic parameters in people with type 2 diabetes, prediabetes and normal glucose tolerance. MATERIALS AND METHODS: A total of 49 participants were enrolled in the study. Anthropometric and biochemical parameters including age, sex, body mass index, smoking status, blood pressure, fasting plasma glucose, C‐peptide, insulin, glycated hemoglobin, total cholesterol, triglyceride, high‐density lipoprotein cholesterol and low‐density lipoprotein cholesterol were assessed. The 75 g oral glucose tolerance test was carried out for 2‐h postload glucose level. Homeostatic model assessment was calculated for insulin resistance and β‐cell function. NK cell activity was measured by detecting the circulating interferon‐gamma level secreted from NK cells. RESULTS: NK cell activity was lower in patients with type 2 diabetes (768.01 ± 650.35) compared with those with prediabetes (2,396.08 ± 653.76, P < 0.001) and normal glucose tolerance (2,435.31 ± 633.22, P < 0.001). In patients with type 2 diabetes, there was a significant inverse linear relationship between NK cell activity and fasting plasma glucose, glycated hemoglobin, and 2‐h postload glucose level (all P < 0.001). Multiple regression analysis showed glycated hemoglobin to be an independent predictor of NK cell activity in patients with type 2 diabetes. CONCLUSIONS: Compared with individuals with normal glucose tolerance or prediabetes, type 2 diabetes patients have a reduced NK cell activity, and it is significantly related to glucose control. John Wiley and Sons Inc. 2019-02-05 2019-09 /pmc/articles/PMC6717814/ /pubmed/30618112 http://dx.doi.org/10.1111/jdi.13002 Text en © 2019 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Articles Kim, Jung Hye Park, Kahui Lee, Sang Bae Kang, Shinae Park, Jong Suk Ahn, Chul Woo Nam, Ji Sun Relationship between natural killer cell activity and glucose control in patients with type 2 diabetes and prediabetes |
title | Relationship between natural killer cell activity and glucose control in patients with type 2 diabetes and prediabetes |
title_full | Relationship between natural killer cell activity and glucose control in patients with type 2 diabetes and prediabetes |
title_fullStr | Relationship between natural killer cell activity and glucose control in patients with type 2 diabetes and prediabetes |
title_full_unstemmed | Relationship between natural killer cell activity and glucose control in patients with type 2 diabetes and prediabetes |
title_short | Relationship between natural killer cell activity and glucose control in patients with type 2 diabetes and prediabetes |
title_sort | relationship between natural killer cell activity and glucose control in patients with type 2 diabetes and prediabetes |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717814/ https://www.ncbi.nlm.nih.gov/pubmed/30618112 http://dx.doi.org/10.1111/jdi.13002 |
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