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Quantitative magnetic resonance assessment of brain atrophy related to selected aspects of disability in patients with multiple sclerosis: preliminary results

PURPOSE: The aim of this volumetric study was to evaluate the relationship between brain atrophy quantification in multiple sclerosis (MS) patients and the progression of disability measured by neurological standardised tests. MATERIAL AND METHODS: Seventeen patients (mean age 40.89 years) with clin...

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Autores principales: Marciniewicz, Ewelina, Pokryszko-Dragan, Anna, Podgórski, Przemysław, Małyszczak, Krzysztof, Zimny, Anna, Kołtowska, Anna, Budrewicz, Sławomir, Sąsiadek, Marek, Bladowska, Joanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717938/
https://www.ncbi.nlm.nih.gov/pubmed/31481987
http://dx.doi.org/10.5114/pjr.2019.84274
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author Marciniewicz, Ewelina
Pokryszko-Dragan, Anna
Podgórski, Przemysław
Małyszczak, Krzysztof
Zimny, Anna
Kołtowska, Anna
Budrewicz, Sławomir
Sąsiadek, Marek
Bladowska, Joanna
author_facet Marciniewicz, Ewelina
Pokryszko-Dragan, Anna
Podgórski, Przemysław
Małyszczak, Krzysztof
Zimny, Anna
Kołtowska, Anna
Budrewicz, Sławomir
Sąsiadek, Marek
Bladowska, Joanna
author_sort Marciniewicz, Ewelina
collection PubMed
description PURPOSE: The aim of this volumetric study was to evaluate the relationship between brain atrophy quantification in multiple sclerosis (MS) patients and the progression of disability measured by neurological standardised tests. MATERIAL AND METHODS: Seventeen patients (mean age 40.89 years) with clinically definite MS and 24 control subjects (mean age 38.45 years) were enrolled in the study. Brain examinations were performed on a 1.5T MR scanner. Automatic brain segmentation was done using FreeSurfer. Neurological disability was assessed in all patients in baseline and after a median follow-up of two years, using EDSS score evaluation. RESULTS: In MS patients we found significantly (p < 0.05) higher atrophy rates in many brain areas compared with the control group. The white matter did not show any significant rate of volume loss in MS patients compared to healthy controls. Significant changes were found only in grey matter volume in MS subjects. At the follow-up evaluation after two years MS patients with deterioration in disability revealed significantly decreased cerebral volume in 14 grey matter areas at baseline magnetic resonance imaging (MRI) compared to MS subjects without disability progression. CONCLUSIONS: Grey matter atrophy is associated with the degree of disability in MS patients. Our results suggest that morphometric measurements of brain volume could be a promising non-invasive biomarker in assessing the volumetric changes in MS patients as related to disability progression in the course of the disease.
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spelling pubmed-67179382019-09-03 Quantitative magnetic resonance assessment of brain atrophy related to selected aspects of disability in patients with multiple sclerosis: preliminary results Marciniewicz, Ewelina Pokryszko-Dragan, Anna Podgórski, Przemysław Małyszczak, Krzysztof Zimny, Anna Kołtowska, Anna Budrewicz, Sławomir Sąsiadek, Marek Bladowska, Joanna Pol J Radiol Original Paper PURPOSE: The aim of this volumetric study was to evaluate the relationship between brain atrophy quantification in multiple sclerosis (MS) patients and the progression of disability measured by neurological standardised tests. MATERIAL AND METHODS: Seventeen patients (mean age 40.89 years) with clinically definite MS and 24 control subjects (mean age 38.45 years) were enrolled in the study. Brain examinations were performed on a 1.5T MR scanner. Automatic brain segmentation was done using FreeSurfer. Neurological disability was assessed in all patients in baseline and after a median follow-up of two years, using EDSS score evaluation. RESULTS: In MS patients we found significantly (p < 0.05) higher atrophy rates in many brain areas compared with the control group. The white matter did not show any significant rate of volume loss in MS patients compared to healthy controls. Significant changes were found only in grey matter volume in MS subjects. At the follow-up evaluation after two years MS patients with deterioration in disability revealed significantly decreased cerebral volume in 14 grey matter areas at baseline magnetic resonance imaging (MRI) compared to MS subjects without disability progression. CONCLUSIONS: Grey matter atrophy is associated with the degree of disability in MS patients. Our results suggest that morphometric measurements of brain volume could be a promising non-invasive biomarker in assessing the volumetric changes in MS patients as related to disability progression in the course of the disease. Termedia Publishing House 2019-04-02 /pmc/articles/PMC6717938/ /pubmed/31481987 http://dx.doi.org/10.5114/pjr.2019.84274 Text en Copyright © Polish Medical Society of Radiology 2019 https://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No Derivatives 4.0 International (CC BY-NC-ND 4.0). License allowing third parties to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.
spellingShingle Original Paper
Marciniewicz, Ewelina
Pokryszko-Dragan, Anna
Podgórski, Przemysław
Małyszczak, Krzysztof
Zimny, Anna
Kołtowska, Anna
Budrewicz, Sławomir
Sąsiadek, Marek
Bladowska, Joanna
Quantitative magnetic resonance assessment of brain atrophy related to selected aspects of disability in patients with multiple sclerosis: preliminary results
title Quantitative magnetic resonance assessment of brain atrophy related to selected aspects of disability in patients with multiple sclerosis: preliminary results
title_full Quantitative magnetic resonance assessment of brain atrophy related to selected aspects of disability in patients with multiple sclerosis: preliminary results
title_fullStr Quantitative magnetic resonance assessment of brain atrophy related to selected aspects of disability in patients with multiple sclerosis: preliminary results
title_full_unstemmed Quantitative magnetic resonance assessment of brain atrophy related to selected aspects of disability in patients with multiple sclerosis: preliminary results
title_short Quantitative magnetic resonance assessment of brain atrophy related to selected aspects of disability in patients with multiple sclerosis: preliminary results
title_sort quantitative magnetic resonance assessment of brain atrophy related to selected aspects of disability in patients with multiple sclerosis: preliminary results
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717938/
https://www.ncbi.nlm.nih.gov/pubmed/31481987
http://dx.doi.org/10.5114/pjr.2019.84274
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