Cargando…
Quantitative magnetic resonance assessment of brain atrophy related to selected aspects of disability in patients with multiple sclerosis: preliminary results
PURPOSE: The aim of this volumetric study was to evaluate the relationship between brain atrophy quantification in multiple sclerosis (MS) patients and the progression of disability measured by neurological standardised tests. MATERIAL AND METHODS: Seventeen patients (mean age 40.89 years) with clin...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Termedia Publishing House
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717938/ https://www.ncbi.nlm.nih.gov/pubmed/31481987 http://dx.doi.org/10.5114/pjr.2019.84274 |
_version_ | 1783447645412392960 |
---|---|
author | Marciniewicz, Ewelina Pokryszko-Dragan, Anna Podgórski, Przemysław Małyszczak, Krzysztof Zimny, Anna Kołtowska, Anna Budrewicz, Sławomir Sąsiadek, Marek Bladowska, Joanna |
author_facet | Marciniewicz, Ewelina Pokryszko-Dragan, Anna Podgórski, Przemysław Małyszczak, Krzysztof Zimny, Anna Kołtowska, Anna Budrewicz, Sławomir Sąsiadek, Marek Bladowska, Joanna |
author_sort | Marciniewicz, Ewelina |
collection | PubMed |
description | PURPOSE: The aim of this volumetric study was to evaluate the relationship between brain atrophy quantification in multiple sclerosis (MS) patients and the progression of disability measured by neurological standardised tests. MATERIAL AND METHODS: Seventeen patients (mean age 40.89 years) with clinically definite MS and 24 control subjects (mean age 38.45 years) were enrolled in the study. Brain examinations were performed on a 1.5T MR scanner. Automatic brain segmentation was done using FreeSurfer. Neurological disability was assessed in all patients in baseline and after a median follow-up of two years, using EDSS score evaluation. RESULTS: In MS patients we found significantly (p < 0.05) higher atrophy rates in many brain areas compared with the control group. The white matter did not show any significant rate of volume loss in MS patients compared to healthy controls. Significant changes were found only in grey matter volume in MS subjects. At the follow-up evaluation after two years MS patients with deterioration in disability revealed significantly decreased cerebral volume in 14 grey matter areas at baseline magnetic resonance imaging (MRI) compared to MS subjects without disability progression. CONCLUSIONS: Grey matter atrophy is associated with the degree of disability in MS patients. Our results suggest that morphometric measurements of brain volume could be a promising non-invasive biomarker in assessing the volumetric changes in MS patients as related to disability progression in the course of the disease. |
format | Online Article Text |
id | pubmed-6717938 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Termedia Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-67179382019-09-03 Quantitative magnetic resonance assessment of brain atrophy related to selected aspects of disability in patients with multiple sclerosis: preliminary results Marciniewicz, Ewelina Pokryszko-Dragan, Anna Podgórski, Przemysław Małyszczak, Krzysztof Zimny, Anna Kołtowska, Anna Budrewicz, Sławomir Sąsiadek, Marek Bladowska, Joanna Pol J Radiol Original Paper PURPOSE: The aim of this volumetric study was to evaluate the relationship between brain atrophy quantification in multiple sclerosis (MS) patients and the progression of disability measured by neurological standardised tests. MATERIAL AND METHODS: Seventeen patients (mean age 40.89 years) with clinically definite MS and 24 control subjects (mean age 38.45 years) were enrolled in the study. Brain examinations were performed on a 1.5T MR scanner. Automatic brain segmentation was done using FreeSurfer. Neurological disability was assessed in all patients in baseline and after a median follow-up of two years, using EDSS score evaluation. RESULTS: In MS patients we found significantly (p < 0.05) higher atrophy rates in many brain areas compared with the control group. The white matter did not show any significant rate of volume loss in MS patients compared to healthy controls. Significant changes were found only in grey matter volume in MS subjects. At the follow-up evaluation after two years MS patients with deterioration in disability revealed significantly decreased cerebral volume in 14 grey matter areas at baseline magnetic resonance imaging (MRI) compared to MS subjects without disability progression. CONCLUSIONS: Grey matter atrophy is associated with the degree of disability in MS patients. Our results suggest that morphometric measurements of brain volume could be a promising non-invasive biomarker in assessing the volumetric changes in MS patients as related to disability progression in the course of the disease. Termedia Publishing House 2019-04-02 /pmc/articles/PMC6717938/ /pubmed/31481987 http://dx.doi.org/10.5114/pjr.2019.84274 Text en Copyright © Polish Medical Society of Radiology 2019 https://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No Derivatives 4.0 International (CC BY-NC-ND 4.0). License allowing third parties to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially. |
spellingShingle | Original Paper Marciniewicz, Ewelina Pokryszko-Dragan, Anna Podgórski, Przemysław Małyszczak, Krzysztof Zimny, Anna Kołtowska, Anna Budrewicz, Sławomir Sąsiadek, Marek Bladowska, Joanna Quantitative magnetic resonance assessment of brain atrophy related to selected aspects of disability in patients with multiple sclerosis: preliminary results |
title | Quantitative magnetic resonance assessment of brain atrophy related to selected aspects of disability in patients with multiple sclerosis: preliminary results |
title_full | Quantitative magnetic resonance assessment of brain atrophy related to selected aspects of disability in patients with multiple sclerosis: preliminary results |
title_fullStr | Quantitative magnetic resonance assessment of brain atrophy related to selected aspects of disability in patients with multiple sclerosis: preliminary results |
title_full_unstemmed | Quantitative magnetic resonance assessment of brain atrophy related to selected aspects of disability in patients with multiple sclerosis: preliminary results |
title_short | Quantitative magnetic resonance assessment of brain atrophy related to selected aspects of disability in patients with multiple sclerosis: preliminary results |
title_sort | quantitative magnetic resonance assessment of brain atrophy related to selected aspects of disability in patients with multiple sclerosis: preliminary results |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717938/ https://www.ncbi.nlm.nih.gov/pubmed/31481987 http://dx.doi.org/10.5114/pjr.2019.84274 |
work_keys_str_mv | AT marciniewiczewelina quantitativemagneticresonanceassessmentofbrainatrophyrelatedtoselectedaspectsofdisabilityinpatientswithmultiplesclerosispreliminaryresults AT pokryszkodragananna quantitativemagneticresonanceassessmentofbrainatrophyrelatedtoselectedaspectsofdisabilityinpatientswithmultiplesclerosispreliminaryresults AT podgorskiprzemysław quantitativemagneticresonanceassessmentofbrainatrophyrelatedtoselectedaspectsofdisabilityinpatientswithmultiplesclerosispreliminaryresults AT małyszczakkrzysztof quantitativemagneticresonanceassessmentofbrainatrophyrelatedtoselectedaspectsofdisabilityinpatientswithmultiplesclerosispreliminaryresults AT zimnyanna quantitativemagneticresonanceassessmentofbrainatrophyrelatedtoselectedaspectsofdisabilityinpatientswithmultiplesclerosispreliminaryresults AT kołtowskaanna quantitativemagneticresonanceassessmentofbrainatrophyrelatedtoselectedaspectsofdisabilityinpatientswithmultiplesclerosispreliminaryresults AT budrewiczsławomir quantitativemagneticresonanceassessmentofbrainatrophyrelatedtoselectedaspectsofdisabilityinpatientswithmultiplesclerosispreliminaryresults AT sasiadekmarek quantitativemagneticresonanceassessmentofbrainatrophyrelatedtoselectedaspectsofdisabilityinpatientswithmultiplesclerosispreliminaryresults AT bladowskajoanna quantitativemagneticresonanceassessmentofbrainatrophyrelatedtoselectedaspectsofdisabilityinpatientswithmultiplesclerosispreliminaryresults |