Comparison of Iridium(I) Catalysts in Temperature Mediated Hydrogen Isotope Exchange Reactions

The reactivity and selectivity of iridium(I) catalysed hydrogen isotope exchange (HIE) reactions can be varied by using wide range of reaction temperatures. Herein, we have done a detailed comparison study with common iridium(I) catalysts (1–6) which will help us to understand and optimize the appro...

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Autores principales: Valero, Mégane, Mishra, Anurag, Blass, Jennifer, Weck, Remo, Derdau, Volker
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718078/
https://www.ncbi.nlm.nih.gov/pubmed/31497473
http://dx.doi.org/10.1002/open.201900204
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author Valero, Mégane
Mishra, Anurag
Blass, Jennifer
Weck, Remo
Derdau, Volker
author_facet Valero, Mégane
Mishra, Anurag
Blass, Jennifer
Weck, Remo
Derdau, Volker
author_sort Valero, Mégane
collection PubMed
description The reactivity and selectivity of iridium(I) catalysed hydrogen isotope exchange (HIE) reactions can be varied by using wide range of reaction temperatures. Herein, we have done a detailed comparison study with common iridium(I) catalysts (1–6) which will help us to understand and optimize the approaches of either high selectivity or maximum deuterium incorporation. We have demonstrated that the temperature window for these studied iridium(I) catalysts is surprisingly very broad. This principle was further proven in some HIE reactions on complex drug molecules.
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spelling pubmed-67180782019-09-06 Comparison of Iridium(I) Catalysts in Temperature Mediated Hydrogen Isotope Exchange Reactions Valero, Mégane Mishra, Anurag Blass, Jennifer Weck, Remo Derdau, Volker ChemistryOpen Full Papers The reactivity and selectivity of iridium(I) catalysed hydrogen isotope exchange (HIE) reactions can be varied by using wide range of reaction temperatures. Herein, we have done a detailed comparison study with common iridium(I) catalysts (1–6) which will help us to understand and optimize the approaches of either high selectivity or maximum deuterium incorporation. We have demonstrated that the temperature window for these studied iridium(I) catalysts is surprisingly very broad. This principle was further proven in some HIE reactions on complex drug molecules. John Wiley and Sons Inc. 2019-08-01 /pmc/articles/PMC6718078/ /pubmed/31497473 http://dx.doi.org/10.1002/open.201900204 Text en © 2019 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Full Papers
Valero, Mégane
Mishra, Anurag
Blass, Jennifer
Weck, Remo
Derdau, Volker
Comparison of Iridium(I) Catalysts in Temperature Mediated Hydrogen Isotope Exchange Reactions
title Comparison of Iridium(I) Catalysts in Temperature Mediated Hydrogen Isotope Exchange Reactions
title_full Comparison of Iridium(I) Catalysts in Temperature Mediated Hydrogen Isotope Exchange Reactions
title_fullStr Comparison of Iridium(I) Catalysts in Temperature Mediated Hydrogen Isotope Exchange Reactions
title_full_unstemmed Comparison of Iridium(I) Catalysts in Temperature Mediated Hydrogen Isotope Exchange Reactions
title_short Comparison of Iridium(I) Catalysts in Temperature Mediated Hydrogen Isotope Exchange Reactions
title_sort comparison of iridium(i) catalysts in temperature mediated hydrogen isotope exchange reactions
topic Full Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718078/
https://www.ncbi.nlm.nih.gov/pubmed/31497473
http://dx.doi.org/10.1002/open.201900204
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