Case series of sebelipase alfa hypersensitivity reactions and successful sebelipase alfa rapid desensitization

Allergic immune‐mediated hypersensitivity reactions are known potential complications of enzyme replacement therapy. Sebelipase alfa, recombinant lysosomal acid lipase (LAL), is a potentially life‐altering treatment for patients with LAL deficiency. There is very little information on the diagnosis...

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Autores principales: Huffaker, Michelle F., Liu, Anne Y., Enns, Gregory M., Vijay, Suresh, Amor, Antonio J., Adkinson, N. Franklin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2019
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718112/
https://www.ncbi.nlm.nih.gov/pubmed/31497479
http://dx.doi.org/10.1002/jmd2.12066
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author Huffaker, Michelle F.
Liu, Anne Y.
Enns, Gregory M.
Vijay, Suresh
Amor, Antonio J.
Adkinson, N. Franklin
author_facet Huffaker, Michelle F.
Liu, Anne Y.
Enns, Gregory M.
Vijay, Suresh
Amor, Antonio J.
Adkinson, N. Franklin
author_sort Huffaker, Michelle F.
collection PubMed
description Allergic immune‐mediated hypersensitivity reactions are known potential complications of enzyme replacement therapy. Sebelipase alfa, recombinant lysosomal acid lipase (LAL), is a potentially life‐altering treatment for patients with LAL deficiency. There is very little information on the diagnosis and management of immediate hypersensitivity reactions to this drug. Here we present three unique cases of hypersensitivity reactions to sebelipase alfa, spanning a broad age spectrum from infancy to adulthood, each managed with successful rapid desensitization.
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spelling pubmed-67181122019-09-06 Case series of sebelipase alfa hypersensitivity reactions and successful sebelipase alfa rapid desensitization Huffaker, Michelle F. Liu, Anne Y. Enns, Gregory M. Vijay, Suresh Amor, Antonio J. Adkinson, N. Franklin JIMD Rep Case Reports Allergic immune‐mediated hypersensitivity reactions are known potential complications of enzyme replacement therapy. Sebelipase alfa, recombinant lysosomal acid lipase (LAL), is a potentially life‐altering treatment for patients with LAL deficiency. There is very little information on the diagnosis and management of immediate hypersensitivity reactions to this drug. Here we present three unique cases of hypersensitivity reactions to sebelipase alfa, spanning a broad age spectrum from infancy to adulthood, each managed with successful rapid desensitization. John Wiley & Sons, Inc. 2019-08-01 /pmc/articles/PMC6718112/ /pubmed/31497479 http://dx.doi.org/10.1002/jmd2.12066 Text en © 2019 The Authors. Journal of Inherited Metabolic Disease published by John Wiley & Sons Ltd on behalf of SSIEM. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Reports
Huffaker, Michelle F.
Liu, Anne Y.
Enns, Gregory M.
Vijay, Suresh
Amor, Antonio J.
Adkinson, N. Franklin
Case series of sebelipase alfa hypersensitivity reactions and successful sebelipase alfa rapid desensitization
title Case series of sebelipase alfa hypersensitivity reactions and successful sebelipase alfa rapid desensitization
title_full Case series of sebelipase alfa hypersensitivity reactions and successful sebelipase alfa rapid desensitization
title_fullStr Case series of sebelipase alfa hypersensitivity reactions and successful sebelipase alfa rapid desensitization
title_full_unstemmed Case series of sebelipase alfa hypersensitivity reactions and successful sebelipase alfa rapid desensitization
title_short Case series of sebelipase alfa hypersensitivity reactions and successful sebelipase alfa rapid desensitization
title_sort case series of sebelipase alfa hypersensitivity reactions and successful sebelipase alfa rapid desensitization
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718112/
https://www.ncbi.nlm.nih.gov/pubmed/31497479
http://dx.doi.org/10.1002/jmd2.12066
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