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Isolated branched-chain amino acid intake and muscle protein synthesis in humans: a biochemical review
Alongside a proper diet, ergogenic aids with potential direct and/or indirect physical performance enhancing effects are sought after for improved adaptation to physical training. Nutritional ergogenics include diet composition changes and/or dietary supplementation. Branched-chain amino acids valin...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Instituto Israelita de Ensino e Pesquisa Albert Einstein
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718193/ https://www.ncbi.nlm.nih.gov/pubmed/31508659 http://dx.doi.org/10.31744/einstein_journal/2019RB4898 |
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author | Santos, Carina de Sousa Nascimento, Fabrício Expedito Lopes |
author_facet | Santos, Carina de Sousa Nascimento, Fabrício Expedito Lopes |
author_sort | Santos, Carina de Sousa |
collection | PubMed |
description | Alongside a proper diet, ergogenic aids with potential direct and/or indirect physical performance enhancing effects are sought after for improved adaptation to physical training. Nutritional ergogenics include diet composition changes and/or dietary supplementation. Branched-chain amino acids valine, leucine and isoleucine are widely popular among products with ergogenic claims. Their major marketing appeal derives from allegations that branched-chain amino acids intake combined with resistance physical exercise stimulates muscle protein synthesis. Evidence supporting the efficacy of branched-chain amino acids alone for muscle hypertrophy in humans is somewhat equivocal. This brief review describes physiological and biochemical mechanisms underpinning the effects of complete protein source and branched-chain amino acid intake on skeletal muscle growth in the postabsorptive and post-exercise state. Evidence in favor of or against potential anabolic effects of isolated branched-chain amino acid intake on muscle protein synthesis in humans is also examined. |
format | Online Article Text |
id | pubmed-6718193 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Instituto Israelita de Ensino e Pesquisa Albert Einstein |
record_format | MEDLINE/PubMed |
spelling | pubmed-67181932019-09-17 Isolated branched-chain amino acid intake and muscle protein synthesis in humans: a biochemical review Santos, Carina de Sousa Nascimento, Fabrício Expedito Lopes Einstein (Sao Paulo) Reviewing Basic Sciences Alongside a proper diet, ergogenic aids with potential direct and/or indirect physical performance enhancing effects are sought after for improved adaptation to physical training. Nutritional ergogenics include diet composition changes and/or dietary supplementation. Branched-chain amino acids valine, leucine and isoleucine are widely popular among products with ergogenic claims. Their major marketing appeal derives from allegations that branched-chain amino acids intake combined with resistance physical exercise stimulates muscle protein synthesis. Evidence supporting the efficacy of branched-chain amino acids alone for muscle hypertrophy in humans is somewhat equivocal. This brief review describes physiological and biochemical mechanisms underpinning the effects of complete protein source and branched-chain amino acid intake on skeletal muscle growth in the postabsorptive and post-exercise state. Evidence in favor of or against potential anabolic effects of isolated branched-chain amino acid intake on muscle protein synthesis in humans is also examined. Instituto Israelita de Ensino e Pesquisa Albert Einstein 2019-08-30 /pmc/articles/PMC6718193/ /pubmed/31508659 http://dx.doi.org/10.31744/einstein_journal/2019RB4898 Text en https://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Reviewing Basic Sciences Santos, Carina de Sousa Nascimento, Fabrício Expedito Lopes Isolated branched-chain amino acid intake and muscle protein synthesis in humans: a biochemical review |
title | Isolated branched-chain amino acid intake and muscle protein synthesis in humans: a biochemical review |
title_full | Isolated branched-chain amino acid intake and muscle protein synthesis in humans: a biochemical review |
title_fullStr | Isolated branched-chain amino acid intake and muscle protein synthesis in humans: a biochemical review |
title_full_unstemmed | Isolated branched-chain amino acid intake and muscle protein synthesis in humans: a biochemical review |
title_short | Isolated branched-chain amino acid intake and muscle protein synthesis in humans: a biochemical review |
title_sort | isolated branched-chain amino acid intake and muscle protein synthesis in humans: a biochemical review |
topic | Reviewing Basic Sciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718193/ https://www.ncbi.nlm.nih.gov/pubmed/31508659 http://dx.doi.org/10.31744/einstein_journal/2019RB4898 |
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