DS-1205b, a novel selective inhibitor of AXL kinase, blocks resistance to EGFR-tyrosine kinase inhibitors in a non-small cell lung cancer xenograft model

The AXL receptor tyrosine kinase is involved in signal transduction in malignant cells. Recent studies have shown that the AXL upregulation underlies epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) resistance in EGFR-mutant non-small cell lung cancer (NSCLC). In this study, w...

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Detalles Bibliográficos
Autores principales: Jimbo, Takeshi, Hatanaka, Mana, Komatsu, Takahiro, Taira, Tomoe, Kumazawa, Kentaro, Maeda, Naoyuki, Suzuki, Takashi, Ota, Masahiro, Haginoya, Noriyasu, Isoyama, Takeshi, Fujiwara, Kosaku
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718264/
https://www.ncbi.nlm.nih.gov/pubmed/31497246
http://dx.doi.org/10.18632/oncotarget.27114

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