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Predictive Association of Smoking with Depressive Symptoms: a Longitudinal Study of Adolescent Twins

Longitudinal, genetically informative studies of the association between cigarette smoking and depressive symptoms among adolescents are limited. We examined the longitudinal association of cigarette smoking with subsequent depressive symptoms during adolescence in a Finnish twin cohort. We used pro...

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Autores principales: Ranjit, Anu, Buchwald, Jadwiga, Latvala, Antti, Heikkilä, Kauko, Tuulio-Henriksson, Annamari, Rose, Richard J., Kaprio, Jaakko, Korhonen, Tellervo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718365/
https://www.ncbi.nlm.nih.gov/pubmed/31069603
http://dx.doi.org/10.1007/s11121-019-01020-6
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author Ranjit, Anu
Buchwald, Jadwiga
Latvala, Antti
Heikkilä, Kauko
Tuulio-Henriksson, Annamari
Rose, Richard J.
Kaprio, Jaakko
Korhonen, Tellervo
author_facet Ranjit, Anu
Buchwald, Jadwiga
Latvala, Antti
Heikkilä, Kauko
Tuulio-Henriksson, Annamari
Rose, Richard J.
Kaprio, Jaakko
Korhonen, Tellervo
author_sort Ranjit, Anu
collection PubMed
description Longitudinal, genetically informative studies of the association between cigarette smoking and depressive symptoms among adolescents are limited. We examined the longitudinal association of cigarette smoking with subsequent depressive symptoms during adolescence in a Finnish twin cohort. We used prospective data from the population-based FinnTwin12 study (maximum N = 4152 individuals, 1910 twin pairs). Current smoking status and a number of lifetime cigarettes smoked were assessed at the age of 14 and depressive symptoms at the age of 17. Negative binomial regression was conducted to model the association between smoking behavior and subsequent depressive symptoms among individuals, and within-pair analyses were conducted to control for unmeasured familial confounding. Analyses were adjusted for age, sex, school grades, drinking alcohol to intoxication, health status, family structure, parental education, and smoking, as well as for pre-existing depressiveness. The results of the individual-level analyses showed that cigarette smoking at the age of 14 predicted depressive symptoms at the age of 17. Compared to never smokers, those who had smoked over 50 cigarettes (incidence rate ratio, IRR = 1.43, 95% CI 1.28–1.60) and regular smokers (IRR = 1.46, 95% CI 1.32–1.62) had higher depression scores. The associations were attenuated when adjusted for measured covariates and further reduced in within-pair analyses. In the within-pair results, the estimates were lower within monozygotic (MZ) pairs compared to dizygotic (DZ) pairs, suggesting that shared genetic factors contribute to the associations observed in individual-based analyses. Thus, we conclude that cigarette smoking is associated with subsequent depressive symptoms during adolescence, but the association is not independent of measured confounding factors and shared genetic influences. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s11121-019-01020-6) contains supplementary material, which is available to authorized users.
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spelling pubmed-67183652019-09-19 Predictive Association of Smoking with Depressive Symptoms: a Longitudinal Study of Adolescent Twins Ranjit, Anu Buchwald, Jadwiga Latvala, Antti Heikkilä, Kauko Tuulio-Henriksson, Annamari Rose, Richard J. Kaprio, Jaakko Korhonen, Tellervo Prev Sci Article Longitudinal, genetically informative studies of the association between cigarette smoking and depressive symptoms among adolescents are limited. We examined the longitudinal association of cigarette smoking with subsequent depressive symptoms during adolescence in a Finnish twin cohort. We used prospective data from the population-based FinnTwin12 study (maximum N = 4152 individuals, 1910 twin pairs). Current smoking status and a number of lifetime cigarettes smoked were assessed at the age of 14 and depressive symptoms at the age of 17. Negative binomial regression was conducted to model the association between smoking behavior and subsequent depressive symptoms among individuals, and within-pair analyses were conducted to control for unmeasured familial confounding. Analyses were adjusted for age, sex, school grades, drinking alcohol to intoxication, health status, family structure, parental education, and smoking, as well as for pre-existing depressiveness. The results of the individual-level analyses showed that cigarette smoking at the age of 14 predicted depressive symptoms at the age of 17. Compared to never smokers, those who had smoked over 50 cigarettes (incidence rate ratio, IRR = 1.43, 95% CI 1.28–1.60) and regular smokers (IRR = 1.46, 95% CI 1.32–1.62) had higher depression scores. The associations were attenuated when adjusted for measured covariates and further reduced in within-pair analyses. In the within-pair results, the estimates were lower within monozygotic (MZ) pairs compared to dizygotic (DZ) pairs, suggesting that shared genetic factors contribute to the associations observed in individual-based analyses. Thus, we conclude that cigarette smoking is associated with subsequent depressive symptoms during adolescence, but the association is not independent of measured confounding factors and shared genetic influences. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s11121-019-01020-6) contains supplementary material, which is available to authorized users. Springer US 2019-05-08 2019 /pmc/articles/PMC6718365/ /pubmed/31069603 http://dx.doi.org/10.1007/s11121-019-01020-6 Text en © The Author(s) 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Article
Ranjit, Anu
Buchwald, Jadwiga
Latvala, Antti
Heikkilä, Kauko
Tuulio-Henriksson, Annamari
Rose, Richard J.
Kaprio, Jaakko
Korhonen, Tellervo
Predictive Association of Smoking with Depressive Symptoms: a Longitudinal Study of Adolescent Twins
title Predictive Association of Smoking with Depressive Symptoms: a Longitudinal Study of Adolescent Twins
title_full Predictive Association of Smoking with Depressive Symptoms: a Longitudinal Study of Adolescent Twins
title_fullStr Predictive Association of Smoking with Depressive Symptoms: a Longitudinal Study of Adolescent Twins
title_full_unstemmed Predictive Association of Smoking with Depressive Symptoms: a Longitudinal Study of Adolescent Twins
title_short Predictive Association of Smoking with Depressive Symptoms: a Longitudinal Study of Adolescent Twins
title_sort predictive association of smoking with depressive symptoms: a longitudinal study of adolescent twins
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718365/
https://www.ncbi.nlm.nih.gov/pubmed/31069603
http://dx.doi.org/10.1007/s11121-019-01020-6
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