Replication stress triggers microsatellite destabilization and hypermutation leading to clonal expansion in vitro

Mismatch repair (MMR)-deficient cancers are characterized by microsatellite instability (MSI) and hypermutation. However, it remains unclear how MSI and hypermutation arise and contribute to cancer development. Here, we show that MSI and hypermutation are triggered by replication stress in an MMR-de...

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Detalles Bibliográficos
Autores principales: Matsuno, Yusuke, Atsumi, Yuko, Shimizu, Atsuhiro, Katayama, Kotoe, Fujimori, Haruka, Hyodo, Mai, Minakawa, Yusuke, Nakatsu, Yoshimichi, Kaneko, Syuzo, Hamamoto, Ryuji, Shimamura, Teppei, Miyano, Satoru, Tsuzuki, Teruhisa, Hanaoka, Fumio, Yoshioka, Ken-ichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718401/
https://www.ncbi.nlm.nih.gov/pubmed/31477700
http://dx.doi.org/10.1038/s41467-019-11760-2

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