Acetyl-CoA flux regulates the proteome and acetyl-proteome to maintain intracellular metabolic crosstalk

AT-1/SLC33A1 is a key member of the endoplasmic reticulum (ER) acetylation machinery, transporting acetyl-CoA from the cytosol into the ER lumen where acetyl-CoA serves as the acetyl-group donor for Nε-lysine acetylation. Dysfunctional ER acetylation, as caused by heterozygous or homozygous mutation...

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Detalles Bibliográficos
Autores principales: Dieterich, Inca A., Lawton, Alexis J., Peng, Yajing, Yu, Qing, Rhoads, Timothy W., Overmyer, Katherine A., Cui, Yusi, Armstrong, Eric A., Howell, Porsha R., Burhans, Maggie S., Li, Lingjun, Denu, John M., Coon, Joshua J., Anderson, Rozalyn M., Puglielli, Luigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718414/
https://www.ncbi.nlm.nih.gov/pubmed/31477734
http://dx.doi.org/10.1038/s41467-019-11945-9

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