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Optimisation of robust singleplex and multiplex droplet digital PCR assays for high confidence mutation detection in circulating tumour DNA

Liquid biopsies offer the potential to monitor cancer response and resistance to therapeutics in near real-time. However, the plasma cell free DNA (cfDNA) level can be low and the fraction of circulating tumour DNA (ctDNA) bearing a mutation – lower still. Detection of tumour-derived mutations in ct...

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Detalles Bibliográficos
Autores principales:	Rowlands, Vicky, Rutkowski, Andrzej J., Meuser, Elena, Carr, T. Hedley, Harrington, Elizabeth A., Barrett, J. Carl
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718424/ https://www.ncbi.nlm.nih.gov/pubmed/31477768 http://dx.doi.org/10.1038/s41598-019-49043-x

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