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The molecular origin and taxonomy of mucinous ovarian carcinoma
Mucinous ovarian carcinoma (MOC) is a unique subtype of ovarian cancer with an uncertain etiology, including whether it genuinely arises at the ovary or is metastatic disease from other organs. In addition, the molecular drivers of invasive progression, high-grade and metastatic disease are poorly d...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718426/ https://www.ncbi.nlm.nih.gov/pubmed/31477716 http://dx.doi.org/10.1038/s41467-019-11862-x |
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| author | Cheasley, Dane Wakefield, Matthew J. Ryland, Georgina L. Allan, Prue E. Alsop, Kathryn Amarasinghe, Kaushalya C. Ananda, Sumitra Anglesio, Michael S. Au-Yeung, George Böhm, Maret Bowtell, David D. L. Brand, Alison Chenevix-Trench, Georgia Christie, Michael Chiew, Yoke-Eng Churchman, Michael DeFazio, Anna Demeo, Renee Dudley, Rhiannon Fairweather, Nicole Fedele, Clare G. Fereday, Sian Fox, Stephen B. Gilks, C Blake Gourley, Charlie Hacker, Neville F. Hadley, Alison M. Hendley, Joy Ho, Gwo-Yaw Hughes, Siobhan Hunstman, David G. Hunter, Sally M. Jobling, Tom W. Kalli, Kimberly R. Kaufmann, Scott H. Kennedy, Catherine J. Köbel, Martin Le Page, Cecile Li, Jason Lupat, Richard McNally, Orla M. McAlpine, Jessica N. Mes-Masson, Anne-Marie Mileshkin, Linda Provencher, Diane M. Pyman, Jan Rahimi, Kurosh Rowley, Simone M. Salazar, Carolina Samimi, Goli Saunders, Hugo Semple, Timothy Sharma, Ragwha Sharpe, Alice J. Stephens, Andrew N. Thio, Niko Torres, Michelle C. Traficante, Nadia Xing, Zhongyue Zethoven, Magnus Antill, Yoland C. Scott, Clare L. Campbell, Ian G. Gorringe, Kylie L. |
| author_facet | Cheasley, Dane Wakefield, Matthew J. Ryland, Georgina L. Allan, Prue E. Alsop, Kathryn Amarasinghe, Kaushalya C. Ananda, Sumitra Anglesio, Michael S. Au-Yeung, George Böhm, Maret Bowtell, David D. L. Brand, Alison Chenevix-Trench, Georgia Christie, Michael Chiew, Yoke-Eng Churchman, Michael DeFazio, Anna Demeo, Renee Dudley, Rhiannon Fairweather, Nicole Fedele, Clare G. Fereday, Sian Fox, Stephen B. Gilks, C Blake Gourley, Charlie Hacker, Neville F. Hadley, Alison M. Hendley, Joy Ho, Gwo-Yaw Hughes, Siobhan Hunstman, David G. Hunter, Sally M. Jobling, Tom W. Kalli, Kimberly R. Kaufmann, Scott H. Kennedy, Catherine J. Köbel, Martin Le Page, Cecile Li, Jason Lupat, Richard McNally, Orla M. McAlpine, Jessica N. Mes-Masson, Anne-Marie Mileshkin, Linda Provencher, Diane M. Pyman, Jan Rahimi, Kurosh Rowley, Simone M. Salazar, Carolina Samimi, Goli Saunders, Hugo Semple, Timothy Sharma, Ragwha Sharpe, Alice J. Stephens, Andrew N. Thio, Niko Torres, Michelle C. Traficante, Nadia Xing, Zhongyue Zethoven, Magnus Antill, Yoland C. Scott, Clare L. Campbell, Ian G. Gorringe, Kylie L. |
| author_sort | Cheasley, Dane |
| collection | PubMed |
| description | Mucinous ovarian carcinoma (MOC) is a unique subtype of ovarian cancer with an uncertain etiology, including whether it genuinely arises at the ovary or is metastatic disease from other organs. In addition, the molecular drivers of invasive progression, high-grade and metastatic disease are poorly defined. We perform genetic analysis of MOC across all histological grades, including benign and borderline mucinous ovarian tumors, and compare these to tumors from other potential extra-ovarian sites of origin. Here we show that MOC is distinct from tumors from other sites and supports a progressive model of evolution from borderline precursors to high-grade invasive MOC. Key drivers of progression identified are TP53 mutation and copy number aberrations, including a notable amplicon on 9p13. High copy number aberration burden is associated with worse prognosis in MOC. Our data conclusively demonstrate that MOC arise from benign and borderline precursors at the ovary and are not extra-ovarian metastases. |
| format | Online Article Text |
| id | pubmed-6718426 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2019 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-67184262019-09-04 The molecular origin and taxonomy of mucinous ovarian carcinoma Cheasley, Dane Wakefield, Matthew J. Ryland, Georgina L. Allan, Prue E. Alsop, Kathryn Amarasinghe, Kaushalya C. Ananda, Sumitra Anglesio, Michael S. Au-Yeung, George Böhm, Maret Bowtell, David D. L. Brand, Alison Chenevix-Trench, Georgia Christie, Michael Chiew, Yoke-Eng Churchman, Michael DeFazio, Anna Demeo, Renee Dudley, Rhiannon Fairweather, Nicole Fedele, Clare G. Fereday, Sian Fox, Stephen B. Gilks, C Blake Gourley, Charlie Hacker, Neville F. Hadley, Alison M. Hendley, Joy Ho, Gwo-Yaw Hughes, Siobhan Hunstman, David G. Hunter, Sally M. Jobling, Tom W. Kalli, Kimberly R. Kaufmann, Scott H. Kennedy, Catherine J. Köbel, Martin Le Page, Cecile Li, Jason Lupat, Richard McNally, Orla M. McAlpine, Jessica N. Mes-Masson, Anne-Marie Mileshkin, Linda Provencher, Diane M. Pyman, Jan Rahimi, Kurosh Rowley, Simone M. Salazar, Carolina Samimi, Goli Saunders, Hugo Semple, Timothy Sharma, Ragwha Sharpe, Alice J. Stephens, Andrew N. Thio, Niko Torres, Michelle C. Traficante, Nadia Xing, Zhongyue Zethoven, Magnus Antill, Yoland C. Scott, Clare L. Campbell, Ian G. Gorringe, Kylie L. Nat Commun Article Mucinous ovarian carcinoma (MOC) is a unique subtype of ovarian cancer with an uncertain etiology, including whether it genuinely arises at the ovary or is metastatic disease from other organs. In addition, the molecular drivers of invasive progression, high-grade and metastatic disease are poorly defined. We perform genetic analysis of MOC across all histological grades, including benign and borderline mucinous ovarian tumors, and compare these to tumors from other potential extra-ovarian sites of origin. Here we show that MOC is distinct from tumors from other sites and supports a progressive model of evolution from borderline precursors to high-grade invasive MOC. Key drivers of progression identified are TP53 mutation and copy number aberrations, including a notable amplicon on 9p13. High copy number aberration burden is associated with worse prognosis in MOC. Our data conclusively demonstrate that MOC arise from benign and borderline precursors at the ovary and are not extra-ovarian metastases. Nature Publishing Group UK 2019-09-02 /pmc/articles/PMC6718426/ /pubmed/31477716 http://dx.doi.org/10.1038/s41467-019-11862-x Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| spellingShingle | Article Cheasley, Dane Wakefield, Matthew J. Ryland, Georgina L. Allan, Prue E. Alsop, Kathryn Amarasinghe, Kaushalya C. Ananda, Sumitra Anglesio, Michael S. Au-Yeung, George Böhm, Maret Bowtell, David D. L. Brand, Alison Chenevix-Trench, Georgia Christie, Michael Chiew, Yoke-Eng Churchman, Michael DeFazio, Anna Demeo, Renee Dudley, Rhiannon Fairweather, Nicole Fedele, Clare G. Fereday, Sian Fox, Stephen B. Gilks, C Blake Gourley, Charlie Hacker, Neville F. Hadley, Alison M. Hendley, Joy Ho, Gwo-Yaw Hughes, Siobhan Hunstman, David G. Hunter, Sally M. Jobling, Tom W. Kalli, Kimberly R. Kaufmann, Scott H. Kennedy, Catherine J. Köbel, Martin Le Page, Cecile Li, Jason Lupat, Richard McNally, Orla M. McAlpine, Jessica N. Mes-Masson, Anne-Marie Mileshkin, Linda Provencher, Diane M. Pyman, Jan Rahimi, Kurosh Rowley, Simone M. Salazar, Carolina Samimi, Goli Saunders, Hugo Semple, Timothy Sharma, Ragwha Sharpe, Alice J. Stephens, Andrew N. Thio, Niko Torres, Michelle C. Traficante, Nadia Xing, Zhongyue Zethoven, Magnus Antill, Yoland C. Scott, Clare L. Campbell, Ian G. Gorringe, Kylie L. The molecular origin and taxonomy of mucinous ovarian carcinoma |
| title | The molecular origin and taxonomy of mucinous ovarian carcinoma |
| title_full | The molecular origin and taxonomy of mucinous ovarian carcinoma |
| title_fullStr | The molecular origin and taxonomy of mucinous ovarian carcinoma |
| title_full_unstemmed | The molecular origin and taxonomy of mucinous ovarian carcinoma |
| title_short | The molecular origin and taxonomy of mucinous ovarian carcinoma |
| title_sort | molecular origin and taxonomy of mucinous ovarian carcinoma |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718426/ https://www.ncbi.nlm.nih.gov/pubmed/31477716 http://dx.doi.org/10.1038/s41467-019-11862-x |
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