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A20 deficiency in hematopoietic stem cells causes lymphopenia and myeloproliferation due to elevated Interferon-γ signals

Inflammation and inflammatory cytokines have been shown to exert both positive and negative effects on hematopoietic stem cells (HSCs) and hematopoiesis. While the significance of inflammation driven hematopoiesis has begun to unfold, molecular players that regulate this phenomenon remain largely un...

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Detalles Bibliográficos
Autores principales: Nakagawa, Masahiro Marshall, Rathinam, Chozha Vendan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718430/
https://www.ncbi.nlm.nih.gov/pubmed/31477755
http://dx.doi.org/10.1038/s41598-019-49038-8