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Comparative quantitative systems pharmacology modeling of anti-PCSK9 therapeutic modalities in hypercholesterolemia

Since the discovery of proprotein convertase subtilisin/kexin type 9 (PCSK9) as an attractive target in the treatment of hypercholesterolemia, multiple anti-PCSK9 therapeutic modalities have been pursued in drug development. The objective of this research is to set the stage for the quantitative ben...

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Detalles Bibliográficos
Autores principales:	Sokolov, Victor, Helmlinger, Gabriel, Nilsson, Catarina, Zhudenkov, Kirill, Skrtic, Stanko, Hamrén, Bengt, Peskov, Kirill, Hurt-Camejo, Eva, Jansson-Löfmark, Rasmus
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Biochemistry and Molecular Biology 2019
Materias:	Patient-Oriented and Epidemiological Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718444/ https://www.ncbi.nlm.nih.gov/pubmed/31292220 http://dx.doi.org/10.1194/jlr.M092486

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