Synergistic Effects of Curcumin and Piperine as Potent Acetylcholine and Amyloidogenic Inhibitors With Significant Neuroprotective Activity in SH-SY5Y Cells via Computational Molecular Modeling and in vitro Assay

Hallmarks of Alzheimer’s disease (AD) pathology include acetylcholine (ACh) deficiency and plaque deposition. Emerging studies suggest that acetylcholinesterase (AChE) may interact with amyloid β (Aβ) to promote aggregation of insoluble Aβ plaques in brains of patients. Current therapeutic options a...

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Detalles Bibliográficos
Autores principales: Abdul Manap, Aimi Syamima, Wei Tan, Amelia Cheng, Leong, Weng Hhin, Yin Chia, Adeline Yoke, Vijayabalan, Shantini, Arya, Aditya, Wong, Eng Hwa, Rizwan, Farzana, Bindal, Umesh, Koshy, Shajan, Madhavan, Priya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718453/
https://www.ncbi.nlm.nih.gov/pubmed/31507403
http://dx.doi.org/10.3389/fnagi.2019.00206

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