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Repertoire Sequencing of B Cells Elucidates the Role of UNG and Mismatch Repair Proteins in Somatic Hypermutation in Humans

The generation of high-affinity antibodies depends on somatic hypermutation (SHM). SHM is initiated by the activation-induced cytidine deaminase (AID), which generates uracil (U) lesions in the B-cell receptor (BCR) encoding genes. Error-prone processing of U lesions creates a typical spectrum of po...

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Detalles Bibliográficos
Autores principales:	IJspeert, Hanna, van Schouwenburg, Pauline A., Pico-Knijnenburg, Ingrid, Loeffen, Jan, Brugieres, Laurence, Driessen, Gertjan J., Blattmann, Claudia, Suerink, Manon, Januszkiewicz-Lewandowska, Danuta, Azizi, Amedeo A., Seidel, Marcus G., Jacobs, Heinz, van der Burg, Mirjam
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718458/ https://www.ncbi.nlm.nih.gov/pubmed/31507588 http://dx.doi.org/10.3389/fimmu.2019.01913

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