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Expression, Role, and Regulation of Neutrophil Fcγ Receptors
Neutrophils are best known for their critical role in host defense, for which they utilize multiple innate immune mechanisms, including microbe-associated pattern recognition, phagocytosis, production of reactive oxygen species, and the release of potent proteases, mediators, antimicrobials, and neu...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718464/ https://www.ncbi.nlm.nih.gov/pubmed/31507592 http://dx.doi.org/10.3389/fimmu.2019.01958 |
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author | Wang, Yu Jönsson, Friederike |
author_facet | Wang, Yu Jönsson, Friederike |
author_sort | Wang, Yu |
collection | PubMed |
description | Neutrophils are best known for their critical role in host defense, for which they utilize multiple innate immune mechanisms, including microbe-associated pattern recognition, phagocytosis, production of reactive oxygen species, and the release of potent proteases, mediators, antimicrobials, and neutrophil extracellular traps. Beyond their well-established contribution to innate immunity, neutrophils were more recently reported to interact with various other cell types, including cells from the adaptive immune system, thereby enabling neutrophils to tune the overall immune response of the host. Neutrophils express different receptors for IgG antibodies (Fcγ receptors), which facilitate the engulfment of IgG-opsonized microbes and trigger cell activation upon cross-linking of several receptors. Indeed, FcγRs (via IgG antibodies) confer neutrophils with a key feature of the adaptive immunity: an antigen-specific cell response. This review summarizes the expression and function of FcγRs on human neutrophils in health and disease and how they are affected by polymorphisms in the FCGR loci. Additionally, we will discuss the role of neutrophils in providing help to marginal zone B cells for the production of antibodies, which in turn may trigger neutrophil effector functions when engaging FcγRs. |
format | Online Article Text |
id | pubmed-6718464 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-67184642019-09-10 Expression, Role, and Regulation of Neutrophil Fcγ Receptors Wang, Yu Jönsson, Friederike Front Immunol Immunology Neutrophils are best known for their critical role in host defense, for which they utilize multiple innate immune mechanisms, including microbe-associated pattern recognition, phagocytosis, production of reactive oxygen species, and the release of potent proteases, mediators, antimicrobials, and neutrophil extracellular traps. Beyond their well-established contribution to innate immunity, neutrophils were more recently reported to interact with various other cell types, including cells from the adaptive immune system, thereby enabling neutrophils to tune the overall immune response of the host. Neutrophils express different receptors for IgG antibodies (Fcγ receptors), which facilitate the engulfment of IgG-opsonized microbes and trigger cell activation upon cross-linking of several receptors. Indeed, FcγRs (via IgG antibodies) confer neutrophils with a key feature of the adaptive immunity: an antigen-specific cell response. This review summarizes the expression and function of FcγRs on human neutrophils in health and disease and how they are affected by polymorphisms in the FCGR loci. Additionally, we will discuss the role of neutrophils in providing help to marginal zone B cells for the production of antibodies, which in turn may trigger neutrophil effector functions when engaging FcγRs. Frontiers Media S.A. 2019-08-27 /pmc/articles/PMC6718464/ /pubmed/31507592 http://dx.doi.org/10.3389/fimmu.2019.01958 Text en Copyright © 2019 Wang and Jönsson. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Wang, Yu Jönsson, Friederike Expression, Role, and Regulation of Neutrophil Fcγ Receptors |
title | Expression, Role, and Regulation of Neutrophil Fcγ Receptors |
title_full | Expression, Role, and Regulation of Neutrophil Fcγ Receptors |
title_fullStr | Expression, Role, and Regulation of Neutrophil Fcγ Receptors |
title_full_unstemmed | Expression, Role, and Regulation of Neutrophil Fcγ Receptors |
title_short | Expression, Role, and Regulation of Neutrophil Fcγ Receptors |
title_sort | expression, role, and regulation of neutrophil fcγ receptors |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718464/ https://www.ncbi.nlm.nih.gov/pubmed/31507592 http://dx.doi.org/10.3389/fimmu.2019.01958 |
work_keys_str_mv | AT wangyu expressionroleandregulationofneutrophilfcgreceptors AT jonssonfriederike expressionroleandregulationofneutrophilfcgreceptors |