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Rag1 immunodeficiency‐induced early aging and senescence in zebrafish are dependent on chronic inflammation and oxidative stress
In mammals, recombination activating gene 1 (RAG1) plays a crucial role in adaptive immunity, generating a vast range of immunoglobulins. Rag1 (−/−) zebrafish (Danio rerio) are viable and reach adulthood without obvious signs of infectious disease in standard nonsterile conditions, suggesting that i...
Autores principales: | Novoa, Beatriz, Pereiro, Patricia, López‐Muñoz, Azucena, Varela, Mónica, Forn‐Cuní, Gabriel, Anchelin, Monique, Dios, Sonia, Romero, Alejandro, Martinez‐López, Alicia, Medina‐Gali, Regla María, Collado, Manuel, Coll, Julio, Estepa, Amparo, Cayuela, María Luisa, Mulero, Victoriano, Figueras, Antonio |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718522/ https://www.ncbi.nlm.nih.gov/pubmed/31348603 http://dx.doi.org/10.1111/acel.13020 |
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