Hypothalamic mTORC2 is essential for metabolic health and longevity

The mechanistic target of rapamycin (mTOR) is an evolutionarily conserved protein kinase that regulates growth and metabolism. mTOR is found in two protein complexes, mTORC1 and mTORC2, that have distinct components and substrates and are both inhibited by rapamycin, a macrolide drug that robustly e...

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Detalles Bibliográficos
Autores principales: Chellappa, Karthikeyani, Brinkman, Jacqueline A., Mukherjee, Sarmistha, Morrison, Mark, Alotaibi, Mohammed I., Carbajal, Kathryn A., Alhadeff, Amber L., Perron, Isaac J., Yao, Rebecca, Purdy, Cole S., DeFelice, Denise M., Wakai, Matthew H., Tomasiewicz, Jay, Lin, Amy, Meyer, Emma, Peng, Yajing, Arriola Apelo, Sebastian I., Puglielli, Luigi, Betley, J. Nicholas, Paschos, Georgios K., Baur, Joseph A., Lamming, Dudley W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718533/
https://www.ncbi.nlm.nih.gov/pubmed/31373126
http://dx.doi.org/10.1111/acel.13014

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