Rho‐associated coiled‐coil kinase 1 activation mediates amyloid precursor protein site‐specific Ser655 phosphorylation and triggers amyloid pathology

Rho‐associated coiled‐coil kinase 1 (ROCK1) is proposed to be implicated in Aβ suppression; however, the role for ROCK1 in amyloidogenic metabolism of amyloid precursor protein (APP) to produce Aβ was unknown. In the present study, we showed that ROCK1 kinase activity and its APP binding were enhanc...

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Detalles Bibliográficos
Autores principales: Hu, Yong‐Bo, Ren, Ru‐Jing, Zhang, Yong‐Fang, Huang, Yue, Cui, Hai‐Lun, Ma, Chao, Qiu, Wen‐Ying, Wang, Hao, Cui, Pei‐Jing, Chen, Hong‐Zhuan, Wang, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718535/
https://www.ncbi.nlm.nih.gov/pubmed/31287605
http://dx.doi.org/10.1111/acel.13001

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