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Maternal use of antibiotics and cancer incidence risk in offspring: A population‐based cohort study in Manitoba, Canada

Several epidemiological studies have found an association between maternal antibiotics use during pregnancy and increased risk of certain cancer types, although conclusions differ between studies. We examined this association in a cohort study including 262 116 mother‐child pairs of Manitoba births...

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Autores principales: Ye, Xibiao, Monchka, Barret A., Righolt, Christiaan H., Mahmud, Salaheddin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718549/
https://www.ncbi.nlm.nih.gov/pubmed/31310456
http://dx.doi.org/10.1002/cam4.2412
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author Ye, Xibiao
Monchka, Barret A.
Righolt, Christiaan H.
Mahmud, Salaheddin M.
author_facet Ye, Xibiao
Monchka, Barret A.
Righolt, Christiaan H.
Mahmud, Salaheddin M.
author_sort Ye, Xibiao
collection PubMed
description Several epidemiological studies have found an association between maternal antibiotics use during pregnancy and increased risk of certain cancer types, although conclusions differ between studies. We examined this association in a cohort study including 262 116 mother‐child pairs of Manitoba births between 1996 and 2013. Maternal antibiotics use during prepregnancy (6 months prior to pregnancy) and pregnancy periods was assessed. Children's cancer incidence was tracked up to the end of the follow‐up period (December 2015). We calculated incidence rate and used Cox regression to estimate adjusted hazard ratios (HRs). Antibiotics use during pregnancy was not associated with overall cancer (HR = 1.1, 95% confidence interval 0.9‐1.4), leukemias (1.3, 0.9‐1.8), or acute lymphocytic leukemia (1.1, 0.7‐1.6). The association between antibiotics use and overall cancer risk differed by trimester: 1.5 (1.1‐1.9) in the first, 0.8 (0.6‐1.0) in the second, and 1.1 (0.8‐1.5) in the third trimester. Further research is necessary to confirm the association between first‐trimester exposure and cancer risk after a better controlling of confounding factors.
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spelling pubmed-67185492019-09-06 Maternal use of antibiotics and cancer incidence risk in offspring: A population‐based cohort study in Manitoba, Canada Ye, Xibiao Monchka, Barret A. Righolt, Christiaan H. Mahmud, Salaheddin M. Cancer Med Cancer Prevention Several epidemiological studies have found an association between maternal antibiotics use during pregnancy and increased risk of certain cancer types, although conclusions differ between studies. We examined this association in a cohort study including 262 116 mother‐child pairs of Manitoba births between 1996 and 2013. Maternal antibiotics use during prepregnancy (6 months prior to pregnancy) and pregnancy periods was assessed. Children's cancer incidence was tracked up to the end of the follow‐up period (December 2015). We calculated incidence rate and used Cox regression to estimate adjusted hazard ratios (HRs). Antibiotics use during pregnancy was not associated with overall cancer (HR = 1.1, 95% confidence interval 0.9‐1.4), leukemias (1.3, 0.9‐1.8), or acute lymphocytic leukemia (1.1, 0.7‐1.6). The association between antibiotics use and overall cancer risk differed by trimester: 1.5 (1.1‐1.9) in the first, 0.8 (0.6‐1.0) in the second, and 1.1 (0.8‐1.5) in the third trimester. Further research is necessary to confirm the association between first‐trimester exposure and cancer risk after a better controlling of confounding factors. John Wiley and Sons Inc. 2019-07-16 /pmc/articles/PMC6718549/ /pubmed/31310456 http://dx.doi.org/10.1002/cam4.2412 Text en © 2019 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Cancer Prevention
Ye, Xibiao
Monchka, Barret A.
Righolt, Christiaan H.
Mahmud, Salaheddin M.
Maternal use of antibiotics and cancer incidence risk in offspring: A population‐based cohort study in Manitoba, Canada
title Maternal use of antibiotics and cancer incidence risk in offspring: A population‐based cohort study in Manitoba, Canada
title_full Maternal use of antibiotics and cancer incidence risk in offspring: A population‐based cohort study in Manitoba, Canada
title_fullStr Maternal use of antibiotics and cancer incidence risk in offspring: A population‐based cohort study in Manitoba, Canada
title_full_unstemmed Maternal use of antibiotics and cancer incidence risk in offspring: A population‐based cohort study in Manitoba, Canada
title_short Maternal use of antibiotics and cancer incidence risk in offspring: A population‐based cohort study in Manitoba, Canada
title_sort maternal use of antibiotics and cancer incidence risk in offspring: a population‐based cohort study in manitoba, canada
topic Cancer Prevention
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718549/
https://www.ncbi.nlm.nih.gov/pubmed/31310456
http://dx.doi.org/10.1002/cam4.2412
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