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Diagnostic Criteria for Obesity Disease in Cats

Accumulated visceral and subcutaneous fat masses were measured with computed tomography (CT) in cats with various body condition scores (BCS) from 5/9 to 9/9. BCS does not always reflect visceral fat accumulation which induces pro-inflammatory reactions. Obese cats with accumulated visceral fat show...

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Autores principales: Okada, Yuki, Ueno, Hiromichi, Mizorogi, Takayuki, Ohara, Kenji, Kawasumi, Koh, Arai, Toshiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718553/
https://www.ncbi.nlm.nih.gov/pubmed/31508438
http://dx.doi.org/10.3389/fvets.2019.00284
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author Okada, Yuki
Ueno, Hiromichi
Mizorogi, Takayuki
Ohara, Kenji
Kawasumi, Koh
Arai, Toshiro
author_facet Okada, Yuki
Ueno, Hiromichi
Mizorogi, Takayuki
Ohara, Kenji
Kawasumi, Koh
Arai, Toshiro
author_sort Okada, Yuki
collection PubMed
description Accumulated visceral and subcutaneous fat masses were measured with computed tomography (CT) in cats with various body condition scores (BCS) from 5/9 to 9/9. BCS does not always reflect visceral fat accumulation which induces pro-inflammatory reactions. Obese cats with accumulated visceral fat showed low plasma adiponectin and high serum amyloid A (SAA) concentrations, an inflammatory marker. Based on the above results, new diagnostic criteria for obesity disease were established as follows. For overweight cats with high BCS of >7/9, showing two or more of the following three symptoms, low adiponectin concentrations, hyperlipidemia, and high SAA concentrations, categorizes them as having obesity disease. Cats with BCS 6/9–9/9, without inflammatory reactions, were classified as simple obesity, which is similar to metabolically healthy obesity (MHO) defined in human medicine. Simple obesity group showed significantly higher adiponectin concentrations than those in control group. The obesity disease group showed significantly higher plasma triglyceride (TG) and SAA concentrations and lower concentrations of adiponectin than the control group. Moreover, plasma glucose and malondialdehyde (MDA) concentrations in the obesity disease group were higher than those in healthy control group, although the differences were not statistically significant. Establishing criteria for obesity disease based on visceral fat accumulation and inflammation markers levels contributes to early and correct diagnosis of obesity in cats.
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spelling pubmed-67185532019-09-10 Diagnostic Criteria for Obesity Disease in Cats Okada, Yuki Ueno, Hiromichi Mizorogi, Takayuki Ohara, Kenji Kawasumi, Koh Arai, Toshiro Front Vet Sci Veterinary Science Accumulated visceral and subcutaneous fat masses were measured with computed tomography (CT) in cats with various body condition scores (BCS) from 5/9 to 9/9. BCS does not always reflect visceral fat accumulation which induces pro-inflammatory reactions. Obese cats with accumulated visceral fat showed low plasma adiponectin and high serum amyloid A (SAA) concentrations, an inflammatory marker. Based on the above results, new diagnostic criteria for obesity disease were established as follows. For overweight cats with high BCS of >7/9, showing two or more of the following three symptoms, low adiponectin concentrations, hyperlipidemia, and high SAA concentrations, categorizes them as having obesity disease. Cats with BCS 6/9–9/9, without inflammatory reactions, were classified as simple obesity, which is similar to metabolically healthy obesity (MHO) defined in human medicine. Simple obesity group showed significantly higher adiponectin concentrations than those in control group. The obesity disease group showed significantly higher plasma triglyceride (TG) and SAA concentrations and lower concentrations of adiponectin than the control group. Moreover, plasma glucose and malondialdehyde (MDA) concentrations in the obesity disease group were higher than those in healthy control group, although the differences were not statistically significant. Establishing criteria for obesity disease based on visceral fat accumulation and inflammation markers levels contributes to early and correct diagnosis of obesity in cats. Frontiers Media S.A. 2019-08-27 /pmc/articles/PMC6718553/ /pubmed/31508438 http://dx.doi.org/10.3389/fvets.2019.00284 Text en Copyright © 2019 Okada, Ueno, Mizorogi, Ohara, Kawasumi and Arai. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
Okada, Yuki
Ueno, Hiromichi
Mizorogi, Takayuki
Ohara, Kenji
Kawasumi, Koh
Arai, Toshiro
Diagnostic Criteria for Obesity Disease in Cats
title Diagnostic Criteria for Obesity Disease in Cats
title_full Diagnostic Criteria for Obesity Disease in Cats
title_fullStr Diagnostic Criteria for Obesity Disease in Cats
title_full_unstemmed Diagnostic Criteria for Obesity Disease in Cats
title_short Diagnostic Criteria for Obesity Disease in Cats
title_sort diagnostic criteria for obesity disease in cats
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718553/
https://www.ncbi.nlm.nih.gov/pubmed/31508438
http://dx.doi.org/10.3389/fvets.2019.00284
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